Levothyroxine sodium Chemical Properties
- Melting point:
- 207-210 (dec.)(lit.)
- D20 -4.4° (c = 3 in 70% ethanol)
- d420 2.381
- storage temp.
- cell culture medium: 0.1 mg/mL
- EPA Substance Registry System
- Levothyroxine sodium (55-03-8)
Levothyroxine sodium Usage And Synthesis
Levothyroxine sodium is White Solid
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.
Levothyroxine sodium (Levothroid, Synthroid, Levoxine)
is the sodium salt of the naturally occurring levorotatory
isomer of T4. It is the preparation of choice for
maintenance of plasma T4 and T3 concentrations for
thyroid hormone replacement therapy in hypothyroid
patients. It is absorbed intact from the gastrointestinal
tract, and its long half-life allows for convenient oncedaily
administration. Since much of the T4 is deiodinated
to T3, it is usually unnecessary to use more expensive
preparations containing both T4 and T3.The aim
is to establish euthyroidism with measured serum concentrations
of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.
Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).
Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.
Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.
Veterinary Drugs and Treatments
Levothyroxine sodium is indicated for the treatment of hypothyroidism in all species.
- Levothyroxine sodium
- 3 5-DIIODOTHYROPROPIONIC ACID
- DL-LEVOTHYROXINE SODIUM
- REVERSE T3
- 3 5-DIIODO-L-TYROSINE DIHYDRATE 98
- Sodium bicarbonate
- Sodium benzoate
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