ChemicalBook >  Product Catalog >  API >  Hormones and the Endocrine System >  Thyroid hormone and antithyroid drugs >  Levothyroxine sodium

Levothyroxine sodium

Basic information Safety Related Supplier

Levothyroxine sodium Basic information

Product Name:
Levothyroxine sodium
CAS:
55-03-8
MF:
C15H20I4NNaO9
MW:
888.93
EINECS:
200-221-4
Mol File:
55-03-8.mol
More
Less

Levothyroxine sodium Chemical Properties

Melting point:
207-210 (dec.)(lit.)
alpha 
D20 -4.4° (c = 3 in 70% ethanol)
Density 
d420 2.381
storage temp. 
2-8°C
solubility 
cell culture medium: 0.1 mg/mL
form 
powder
InChIKey
JMHCCAYJTTWMCX-QWPJCUCISA-M
EPA Substance Registry System
Levothyroxine sodium (55-03-8)
More
Less

Safety Information

Safety Statements 
22-24/25
RIDADR 
2811
WGK Germany 
3
RTECS 
YP2833760
3-8-10
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2937909000

MSDS

More
Less

Levothyroxine sodium Usage And Synthesis

Chemical Properties

Levothyroxine sodium  is White Solid

Uses

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

Definition

ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.

Indications

Levothyroxine sodium (Levothroid, Synthroid, Levoxine) is the sodium salt of the naturally occurring levorotatory isomer of T4. It is the preparation of choice for maintenance of plasma T4 and T3 concentrations for thyroid hormone replacement therapy in hypothyroid patients. It is absorbed intact from the gastrointestinal tract, and its long half-life allows for convenient oncedaily administration. Since much of the T4 is deiodinated to T3, it is usually unnecessary to use more expensive preparations containing both T4 and T3.The aim is to establish euthyroidism with measured serum concentrations of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.

brand name

Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).

General Description

Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.

Clinical Use

Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.

Veterinary Drugs and Treatments

Levothyroxine sodium is indicated for the treatment of hypothyroidism in all species.

Levothyroxine sodium Preparation Products And Raw materials

Raw materials

More
Less

Levothyroxine sodium SupplierMore

Shifang ShengYuan Technology Co., Ltd. Gold
Tel:
13402890778,
Email:
1120021438@qq.com
Suzhou Pharmaceutical Technology co.,ltd Gold
Tel:
Email:
lsenfy@126.com
Shanghai Mokay Pharmaceutical Technology Co., Ltd. Gold
Tel:
021-60257269 18601606476
Email:
yl@mkpharma.cn
上海默凯医药科技有限公司 Shanghai Mokai Pharmaceutical Technology Co., Ltd. Gold
Tel:
021-60951261- ;021-60951261-
Email:
nancy@mkpharma.cn;dhn@mkpharma.cn
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Basic information Safety Related Supplier