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Ascorbyl Palmitate

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Ascorbyl Palmitate Basic information

Product Name:
Ascorbyl Palmitate
CAS:
137-66-6
MF:
C22H38O7
MW:
414.53
EINECS:
205-305-4
Mol File:
137-66-6.mol
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Ascorbyl Palmitate Chemical Properties

Melting point:
115-118 °C(lit.)
alpha 
+21~+26°(20℃/D, c=2, C2H5OH)
Boiling point:
512.7±50.0 °C(Predicted)
Density 
1.150±0.06 g/cm3(Predicted)
refractive index 
22.5 ° (C=1, EtOH)
storage temp. 
Store at +15°C to +25°C.
solubility 
Slightly soluble in ethyl alcohol.
pka
3.96±0.10(Predicted)
form 
neat
optical activity
[α]20/D +23±1°, c = 1% in ethanol
BRN 
96552
InChIKey
QAQJMLQRFWZOBN-UWJYYQICSA-N
CAS DataBase Reference
137-66-6(CAS DataBase Reference)
EPA Substance Registry System
Ascorbyl palmitate (137-66-6)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
1
RTECS 
CI7671040
TSCA 
Yes
HS Code 
2936 27 00
Hazardous Substances Data
137-66-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg

MSDS

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Ascorbyl Palmitate Usage And Synthesis

Chemical Properties

Light yellow powder

Chemical Properties

Ascorbyl palmitate is a practically odorless, white to yellowish powder.

Uses

Ascorbyl Palmitate is an ester formed from ascorbic acid (A786990) and palmitic acid (P144500) creating a fat soluble form of vitamin C. Ascorbyl Palmitate is also used as an antioxidant food additiv e.

Uses

ascorbyl palmitate is used as a preservative and an anti-oxidant in cosmetic creams and lotions to prevent rancidity. Ascorbyl palmitate facilitates the incorporation of ingredients such as vitamins A, C, and D into cosmetic formulations. It has no known toxicity.

Uses

Ascorbyl Palmitate is an antioxidant formed by combining ascor- bic acid with palmitic acid. ascorbic acid is not fat soluble but ascor- byl palmitate is, thus combining them produces a fat-soluble antioxidant. it exists as a white or yellowish white powder of citric- like odor. it is used as a preservative for natural oils, edible oils, col- ors, and other substances. it acts synergistically with alpha-tocopherol in oils/fats. it is used in peanut oil at a maximum level of 200 mg/kg individually or in combination.

Definition

A white or yellowish-white powder having a citrus-like odor. Mp 116–117C; soluble in alcohol and in animal and vegetable oils; slightly soluble in water.

Production Methods

Ascorbyl palmitate is prepared synthetically by the reaction of ascorbic acid with sulfuric acid followed by reesterification with palmitic acid.

Pharmaceutical Applications

Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used. It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen. The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced.
The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Ascorbyl palmitate is used in oral pharmaceutical formulations and food products, and is generally regarded as an essentially nontoxic and nonirritant material. The WHO has set an estimated acceptable daily intake for ascorbyl palmitate at up to 1.25 mg/kg bodyweight.
LD50 (mouse, oral): 25 g/kg
LD50 (rat, oral): 10 g/kg

storage

Ascorbyl palmitate is stable in the dry state, but is gradually oxidized and becomes discolored when exposed to light and high humidity. In an unopened container, stored in a cool place, it has a shelf life of at least 12 months. During processing, temperatures greater than 658℃ should be avoided.
The bulk material should be stored in an airtight container at 8–158℃, protected from light.

Incompatibilities

Incompatibilities are known with oxidizing agents; e.g. in solution oxidation is catalyzed by trace metal ions such as Cu2+ and Fe3+.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, rectal, topical preparations). Included in nonparenteral medicines licensed in the UK.

Ascorbyl Palmitate Preparation Products And Raw materials

Raw materials

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Ascorbyl PalmitateSupplierMore

Zhejiang tianxin pharmaceutical co. LTD Gold
Tel:
021-50318873-
Email:
office2@txpharm.com;
Aikon International Limited Gold
Tel:
025-66151770,13813800073//qq:2885670560
Email:
lwan@aikonchem.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
future industrial shanghai co., ltd
Tel:
400-0066-400;021-60496031
Email:
sales@jonln.com;sales@jonln.com
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