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Triethyl orthoformate

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Triethyl orthoformate Basic information

Product Name:
Triethyl orthoformate
CAS:
122-51-0
MF:
C7H16O3
MW:
148.2
EINECS:
204-550-4
Mol File:
122-51-0.mol
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Triethyl orthoformate Chemical Properties

Melting point:
−76 °C(lit.)
Boiling point:
146 °C(lit.)
Density 
0.891 g/mL at 25 °C(lit.)
vapor density 
5.11 (vs air)
vapor pressure 
2.9 mm Hg ( 20 °C)
refractive index 
n20/D 1.391(lit.)
Flash point:
86 °F
storage temp. 
Flammables area
form 
Liquid
color 
Clear colorless
Water Solubility 
1.35 g/L
Sensitive 
Moisture Sensitive
Merck 
14,6884
BRN 
605384
InChIKey
GKASDNZWUGIAMG-UHFFFAOYSA-N
CAS DataBase Reference
122-51-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl orthoformate(122-51-0)
EPA Substance Registry System
Ethyl orthoformate (122-51-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
10-36-36/38
Safety Statements 
16-26-37/39-36-45-36/39
RIDADR 
UN 2524 3/PG 3
WGK Germany 
1
RTECS 
RM6475000
21
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29159080
Toxicity
LD50 orally in rats: 7.06 g/kg (Smyth)

MSDS

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Triethyl orthoformate Usage And Synthesis

Chemical Properties

Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.

Uses

Labelled Prednisolone 21-Sulfate (P703755). Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740).

Uses

A reagent useful for acetylization and imidic ester formation.

General Description

A clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.

Reactivity Profile

Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Flammable, moderate fire risk.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Fractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.

Triethyl orthoformate Preparation Products And Raw materials

Preparation Products

3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE1-CYCLOHEXYLURACILMETHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE4-Acetylphenylboronic acid4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97%2-Formylfuran-5-boronic acidEstazolam2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID4-Methylpyrimidine2-AMINO-3,5-DICYANOPYRIDINEETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)-1-CHLORO-4-ISOCYANOBENZENE4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTERETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE2,4-DIAMINOPYRIMIDINE-5-CARBONITRILEEthyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylateETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE4-Chloro-7-(trifluoromethyl)quinoline4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTERETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACIDDiethoxymethyl acetate3-Aminopyrazole-4-carboxylic acidETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILEETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE5-CARBETHOXYURACIL3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONEN-FORMYLGLYCINE ETHYL ESTER4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE1H-Imidazole-4,5-dicarbonitrileChloromethyltriethoxysilaneETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE

Raw materials

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Shanghai YouPeng Chemical Co. Ltd. Gold
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021-69002118- ;021-69002118-
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Jinan Renyuan Chemical Co., Ltd. Gold
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Changzhou Zidong Lianhua import and Export Co., Ltd Gold
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Shanghai demo pharmaceutical technology co., LTD Gold
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1563259405@qq.com
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