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Amlodipine Besylate

Basic information Description References Safety Related Supplier

Amlodipine Besylate Basic information

Product Name:
Amlodipine Besylate
CAS:
111470-99-6
MF:
C26H31ClN2O8S
MW:
567.05094
EINECS:
1312995-182-4
Mol File:
111470-99-6.mol
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Amlodipine Besylate Chemical Properties

Melting point:
199-201°C
storage temp. 
Store at RT
solubility 
DMSO: 20 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.
Merck 
14,491
InChIKey
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
CAS DataBase Reference
111470-99-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
US7967700
HS Code 
29333990
Hazardous Substances Data
111470-99-6(Hazardous Substances Data)

MSDS

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Amlodipine Besylate Usage And Synthesis

Description

Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers. One of the amlodipine product on the market is Norvasc®.
Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD.

References

[1] http://www.webmd.com/drugs/2/drug-5891/amlodipine-oral/details
[2] https://www.drugs.com/amlodipine.html
[3] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4b30c56-7403-4f69-9a8e-3d82a37e8bc5#section-1

Description

Anilodipine besylate is a new, once-daily, dihydropyridine calcium antagonist useful in the treatment of hypertension and angina.

Chemical Properties

White Crystalline Solid

Originator

Pfizer (USA)

Uses

A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive

Uses

Angiotensin II inhibitor prodrug, antihypertensive

Uses

Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Definition

ChEBI: The benzenesulfonate salt of amlodipine.

brand name

Norvasc (Pfizer);Istin.

Biological Activity

L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).

Veterinary Drugs and Treatments

Oral amlodipine appears to be a useful agent in the treatment of hypertension in cats and many consider it the drug of choice for this indication. In pharmacokinetic studies, amlodipine has decreased blood pressure in dogs with chronic renal disease, but its efficacy in treating hypertensive dogs has been disappointing.
Hypertension in cats is usually secondary to other diseases (often renal failure or cardiac causes such as thyrotoxic cardiomyopathy or primary hypertrophic cardiomyopathy, etc.) and is most often seen in middle-aged or geriatric cats. These animals often present with acute clinical signs such as blindness, seizures, collapse or paresis. A cat is generally considered hypertensive if systolic blood pressure is >160 mmHg. Early reports indicate that if antihypertensive therapy is begun acutely, some vision may be restored in about 50% of cases of blindness secondary to hypertension.

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Amlodipine BesylateSupplierMore

GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD Gold
Tel:
; ;
Email:
dylan@gzbr.com.cn;cdm@gzbr.com.cn;goldg@gzbr.com.cn
Products Intro:
Product Name:Amlodipine Besylate
CAS:111470-99-6
Purity:98% Package:25KG/1.00;
Hangzhou Fuze Pharmaceutical Technology Co., Ltd. Gold
Tel:
0571-82870240
Email:
1525309486@qq.com
Products Intro:
Product Name:Amlodipine Besylate
CAS:111470-99-6
Package:1g/200;10g/1150;100g/3800
Shanghai Boyle Chemical Co., Ltd.
Tel:
Email:
sales@boylechem.com
Products Intro:
Product Name:Amlodipine besilate
CAS:111470-99-6
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro:
Product Name:AMlodipine Besylate
CAS:111470-99-6
Purity:98.0%(LC&N) Package:1G,5G
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
Products Intro:
Product Name:AMlodipine Besylate
CAS:111470-99-6
Purity:>98.0%(LC)(N) Package:1g;5g Remarks:A2353
Basic information Description References Safety Related Supplier