OXOTREMORINE

Basic information Safety Related Supplier

OXOTREMORINE Basic information

Product Name:
OXOTREMORINE
CAS:
70-22-4
MF:
C12H18N2O
MW:
206.28
EINECS:
200-728-0
Mol File:
70-22-4.mol
More
Less

OXOTREMORINE Chemical Properties

Boiling point:
124 °C0.1 mm Hg(lit.)
Density 
1 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.517(lit.)
Flash point:
113 °C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
liquid
color 
clear, light yellow
Merck 
13,7020
More
Less

Safety Information

Hazard Codes 
T+,C
Risk Statements 
28-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2810 6.1/PG 1
WGK Germany 
3
RTECS 
UY5950100
10-23
HazardClass 
6.1(a)
PackingGroup 
I

MSDS

More
Less

OXOTREMORINE Usage And Synthesis

General Description

Oxotremorine [1-(-pyrrolidono)-4-pyrrolidino-2-butyne] has been regarded as a CNS muscarinicstimulant. Its action on the brain produces tremors inexperimental animals. It increases ACh brain levels in ratsup to 40% and has been studied as a drug in the treatment ofAlzheimer disease. Although earlier studies suggested thatthis approach of elevating levels of ACh to treat Alzheimerdisease is useful, this belief was highly disputed by manyresearchers.

Clinical Use

Nevertheless, oxotremorine, as a cholinergicagonist, facilitates memory storage. These findings haveserved as important leads in the development of agents usefulin treating Alzheimer disease. Although it possessesgroups that do not occur in other highly active muscarinicagents, oxotremorine’s trans conformation shows that distancesbetween possible active centers correspond with (+)-muscarine.

More
Less

OXOTREMORINESupplierMore

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:
3bsc@sina.com
Shenzhen Nexconn Pharmatechs Ltd
Tel:
15013857715
Email:
admin@nexconn.com
Basic information Safety Related Supplier