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米帕林盐酸盐

米帕林盐酸盐

中文名称:米帕林盐酸盐
英文名称:Mepacrine hydrochloride
CAS号:6151-30-0
分子式:C23H36Cl3N3O3
分子量:508.91
EINECS号:
Mol文件:6151-30-0.mol
米帕林盐酸盐 结构式

米帕林盐酸盐 性质

熔点 247 °C
储存条件 Store at -20°C
溶解度 DMSO:10mg/mL(19.65mM);;
水溶解性 2.8 g/100 mL
CAS 数据库 6151-30-0(CAS DataBase Reference)

米帕林盐酸盐 用途与合成方法

Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) 是一种抗疟剂 (antimalarial),在体内外均具有抗肿瘤作用。Quinacrine hydrochloride hydrate 抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡 (apoptosis)。

Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .

Cell Viability Assay

Cell Line: SGC-7901 cells
Concentration: 0, 5, 10, 15, and 20 μM
Incubation Time: 24 hours
Result: Cell viability was inhibited in a dose-dependent manner, and the mean IC 50 value is 16.18 μM.

Apoptosis Analysis

Cell Line: SGC-7901 cells
Concentration: 7.5 and 15 μM
Incubation Time: 24 hours
Result: The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%.

Western Blot Analysis

Cell Line: SGC-7901 cells
Concentration: 15 μM
Incubation Time: 24 hours
Result: The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24.
The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19.
The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.

Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.

Animal Model: Female SCID mice with acute myeloid leukemia (AML)-PS model
Dosage: 100 mg/kg
Administration: Administered by oral gavage (po); three times a week for two consecutive weeks
Result: In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.

安全信息

危险品标志Xn
危险类别码22-36/37/38
安全说明26-37/39

MSDS信息

语言:English
提供商:ACROS

米帕林盐酸盐 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-16 S5435 米帕林盐酸盐 6151-30-0 25mg 794.67

米帕林盐酸盐供应商 更多

斯百全化学(上海)有限公司
联系电话:021-021-021-67601398-809-809-809 15221380277
产品介绍:
英文名称:Quinacrine Hydrochloride, Dihydrate
CAS:6151-30-0
包装信息:25KGBL
备注:Q1013
北京普西唐生物科技有限公司
联系电话:010-60605840 18892239720
产品介绍:
中文名称:奎纳克林二盐酸盐二水合物
英文名称:Quinacrine hydrochloride hydrate
CAS:6151-30-0
包装信息:1g;5g;10g
威尔曼医药集团有限公司
联系电话:027-027-83778875 15807197853
产品介绍:
中文名称:米帕林盐酸盐
英文名称:Mepacrine hydrochloride
CAS:6151-30-0
纯度:98%
备注:4562g
上海参比医药科技有限公司(进口产品部)
联系电话: 13368167990
产品介绍:
CAS:6151-30-0
纯度:99% HPLC
包装信息:5KG;1KG
上海杰股生物科技有限公司
联系电话:021-51698675
产品介绍:
英文名称:Mepacrine hydrochloride
CAS:6151-30-0
纯度:97% HPLC
包装信息:1KG;100KG

米帕林盐酸盐生产厂家及价格列表

米帕林盐酸盐
湖北威德利化学试剂有限公司 2024-03-28
米帕林盐酸盐—6151-30-0
湖北魏氏化学试剂股份有限公司 2024-03-28

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