Light yellow liquid or yellow granular material.
Commercial products may be in the form of dusts, sprays,
solutions, wettable powder suspensions or emulsions.
A preemergence herbicide.
EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate.
Selective systemic herbicide used for preemergence control of perennial and annual grasses such as johnsongrass, nutgrass and quackgrass. Also for control of some broadleaved weeds such as chickweed, henbit, lambsquarters, pigweed and purslane. EPTC is also used in vegetable crops, alfalfa, cotton, flax, pineapple, almonds and walnuts.
ChEBI: EPTC is a tertiary amine.
S-Ethyl dipropylthiocarbamate (EPTC) is a pale to dark yellow liquid with an aromatic odour/pleasant scent characteristic to thiocarbamates. EPTC is a commonly used herbicide. EPTC has a pleasant scent and at 20°C is miscible with most organic solvents, including acetone, ethyl alcohol, kerosene, methyl isobutyl ketone (MIBK), and xylene.
EPTC was the first thiocarbamate herbicide developed. EPTC formulations are used for the control of preemergent weeds, especially grasses. EPTC inhibits photosynthesis, respiration, and the synthesis of lipids, proteins, and RNA in these seedlings. Resistant plants are less sensitive to the herbicidal action apparently due to their ability to rapidly metabolise EPTC.
Water insoluble. Slowly decomposes in water to form carbon disulfide and propyl amine. Such decompositions are accelerated by acids.
Eradicane may generate flammable gases with aldehydes, nitrides, and hydrides. Incompatible with acids, peroxides, and acid halides.
SYMPTOMS: Symptoms of exposure to Eradicane may include headache, giddiness, nervousness, blurred vision, weakness, nausea, cramps, diarrhea, sweating, miosis, tearing, salivation, vomiting and cyanosis.
Flash point data are not available for Eradicane, but Eradicane is probably combustible.
Flammability and Explosibility
Non flammable
Herbicide: Some formulations are Restricted Group Pesticides
(RUP). EPTC is a pre-emergence and early post-emergence
herbicide used to control the growth of germinating annual
weeds, including broadleaves, grasses, and sedges. It is
used in every region of the United States in the production
of a wide variety of food crops. The heaviest usage is in the
Corn Belt, Northeastern and Mid-Atlantic states, Coastal
and Northern Great Plains and in the Pacific Northwest on corn, potatoes, sweet potatoes, dry beans, peas, alfalfa, and
snap beans. EPTC is also used on home-grown vegetables
and ornamentals. Not approved for use in EU countries.
Registered for use in the U.S. and other countries
ALIROX®; EPTAM®; EPTAM® 6E;
EPTAM 2.3G (granular, 2.3% by weight); EPTAM 10G
(granular, 10% by weight); ERADICANE®; GENEP®
EPTC; R-1608®; SHORTSTOP®; STAUFFER® R 1608;
TORBIN®
Poison by ingestion,
inhalation, and intravenous routes.
Moderately toxic by skin contact route.
Mutation data reported. An herbicide. When
heated to decomposition it emits very toxic
fumes of NOx and SOx. See also
CARBAMATES
EPTC is a pre-emergence and early
postemergence thiocarbamate herbicide used to control the
growth of germinating annual weeds, including broadleaves, grasses, and sedges. It is used in every region of the
United States in the production of a wide variety of food
crops. The heaviest usage is in the Corn Belt, Northeastern
and Mid-Atlantic states, Coastal and Northern Great Plains
and in the Pacific Northwest on corn, potatoes, sweet potatoes, dry beans, peas, alfalfa, and snap beans. EPTC is also
used on home-grown vegetables and ornamentals. Some
formulations are Restricted Group Pesticides (RUP)
Soil. EPTC is rapidly degraded by soil microbes and fungi yielding carbon dioxide,
ethyl mercaptan and amino residues (Kaufman, 1967; Lee, 1984; Hartley and Kidd, 1987).
Degradation occurs via hydrolysis of the ester linkage forming the corresponding mercaptan,
alkylamine (n-dipropylamine) and carbon dioxide. Transthiolation and oxidation of
the mercaptan forms the alcohol which is further oxidized to afford a metabolic pool
(Kaufman, 1967). EPTC partially degraded in both sterile and nonsterile clay soils. Mineralization
was not observed since carbon dioxide was not detected (MacRae and Alex-
ander, 1965). EPTC sulfoxide was also reported as a metabolite identified in soil (Somasundaram
and Coats, 1991) and in corn plants (Casida et al., 1974). The rapid formation
of carbon dioxide was also observed from the microbial degradation of EPTC by a
microbial metabolite isolated from Jimtown loam soil and designated JE1 (Dick et al.,
1990). These researchers proposed that EPTC hydroxylated at the a-propyl carbon forming
the unstable a-hydroxypropyl EPTC which degrades to N-depropyl EPTC and propionaldehyde.
Metabolization of N-depropyl EPTC yields s-ethyl formic acid and propylamine.
Demethylation of s-ethyl formic acid gives s-methyl formic acid. Propylamine and smethyl
formic acid probably degrades to ammonia and methyl mercaptan, respectively
and carbon dioxide (Dick et al., 1990). The reported half-lives in soil ranged from 2 to 4
weeks in two agricultural soils (Regina heavy clay and Weyburn loam) (Smith and Fitzpatrick,
1970) to 30 days (Jury et al., 1987). Rajagopal et al. (1989) reported that the
persistence of EPTC in soil ranged from <4 to 6 weeks when applied at recommended rates.
Plant. EPTC is rapidly metabolized by plants to carbon dioxide and naturally occurring
plants constituents (Humburg et al., 1989).
Chemical/Physical. Emits toxic fumes of phosphorus and sulfur oxides when heated
to decomposition (Sax and Lewis, 1987).
In the gas phase, EPTC reacts with hydroxyl and/or NO3 radicals but not with ozone.
With hydroxy radicals in the presence of NO3, S-ethyl N-formyl-N-propylthiocarbamate
formed as the major product. With NO3 radicals only, the major product was
C3H7(CHO)NC(O)SC2H5. In addition, a minor product formed tentatively identified as
CH3CH2CH2(CH3CH2C(O))NC(O)SCH2CH3. The calculated photolysis lifetimes of EPTC
in the troposphere with hydroxyl and NO3 radicals are 5.8 hours and 5.0 days, respectively
(Kwok et al., 1992).
A new class of xenobiotic metabolite derived from the
glutathione conjugate is produced by corn, cotton, and
corn cell suspension cultures treated with 14C-EPTC
(S-ethyl dipropylthiocarbamate). This metabolite is
characterized as S-(N,N-dipropylcarbamoyl)-O-
malonyl-3-thiolactic acid and is not detected in
soybean plants or peanut cell suspension cultures. A
second major metabolite of EPTC, S-(N,N-
dipropylcarbamoyl)-N-malonylcysteine, is present in all
tissues.
UN2902 Pesticides, liquid, toxic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required
Thiocarbamate esters are combustible.
They react violently with powerful oxidizers such as calcium hypochlorite. Thermal decomposition of thiocarbamate compounds include carbon disulfide, oxides of sulfur,
oxides of nitrogen, hydrogen sulfide, ammonia, andmethylamine. Thio and dithiocarbamates slowly decompose
in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Flammable gases are generated by the
combination of thiocarbamates with aldehydes, nitrides,
and hydrides. Thiocarbamates are incompatible with acids,
peroxides, and acid halides.
Land burial is acceptable for
small quantities. Larger quantities can be incinerated. (EPTC
is combustible and could be incinerated. Recommendable
method: Incineration. Peer-review: Incineration in a unit witheffluent gas scrubbing is recommendable for large amount.
Containers must be disposed of properly by following package label directions or by contacting your local or federal
environmental control agency, or by contacting your regional
EPA office. Consult with environmental regulatory agencies
for guidance on acceptable disposal practices. Generators of
waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation,
treatment, and waste disposal
