ChemicalBook >  Product Catalog >  Organic Chemistry >  Carboxylic acids and derivatives >  Carboxylic acid derivatives >  4-Aminobenzoic acid

4-Aminobenzoic acid

Basic information Safety Related Supplier

4-Aminobenzoic acid Basic information

Product Name:
4-Aminobenzoic acid
CAS:
150-13-0
MF:
C7H7NO2
MW:
137.14
EINECS:
205-753-0
Mol File:
150-13-0.mol
More
Less

4-Aminobenzoic acid Chemical Properties

Melting point:
187-189 °C(lit.)
Boiling point:
251.96°C (rough estimate)
Density 
1.374 g/mL at 25 °C(lit.)
refractive index 
1.5323 (estimate)
Flash point:
250 °C
storage temp. 
2-8°C
solubility 
95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow
form 
Crystalline Powder
pka
2.50, 4.87(at 25℃)
color 
White to light yellow
Odor
Odorless
PH
3.5 (5g/l, H2O, 20℃)
PH Range
3.5
Water Solubility 
4.7 g/L (20 ºC)
Sensitive 
Air & Light Sensitive
Merck 
14,423
BRN 
471605
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible. Sensitive to light and air. May discolour on exposure to light.
InChIKey
ALYNCZNDIQEVRV-UHFFFAOYSA-N
CAS DataBase Reference
150-13-0(CAS DataBase Reference)
NIST Chemistry Reference
p-Aminobenzoic acid(150-13-0)
EPA Substance Registry System
p-Aminobenzoic acid (150-13-0)
More
Less

Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
DG1400000
TSCA 
Yes
HS Code 
29224995
Hazardous Substances Data
150-13-0(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (g/kg): 2.85, >6.0 orally (Scott, Robbins); LD50 in rabbits (g/kg): 2.0 i.v. (Richards); 1.83 orally (Cronheim)

MSDS

More
Less

4-Aminobenzoic acid Usage And Synthesis

Description

4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position) is an organic compound with the formula H2NC6H4CO2H. PABA is a white solid, although commercial samples can appear gray. It is slightly soluble in water. It consists of a benzene ring substituted with amino and a carboxyl groups. The compound occurs naturally. The potassium salt is used as a drug against fibrotic skin disorders, such as Peyronie's disease, under the trade name Potaba. PABA is also occasionally used in pill form by sufferers of irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels.

Chemical Properties

White to off white crystalline powder

Uses

Widely distributed in nature as a B complex factor. Baker’s yeast contains 5 to 6 ppm, brewer’s yeast from 10 to 100 ppm. Occurs free and in ester form.

Uses

gastric acid secretion inhibitor

Uses

octyl dimethyl PABA (padimate-O; p-aminobenzoic acid) is an FDA-approved sunscreen chemical whose InCI name is now ethylhexyl dimethyl PABA.

Uses

PABA is a sunscreen chemical with an approved usage level of 5 to 15 percent. It is found to be irritating to sensitive skin, has the potential to cause sensitization, and is considered too water soluble. once extremely popular, this ingredient has practically disappeared from sunscreen formulations. PABA is a yellowish or colorless acid found in vitamin B complex.

Indications

PABA preparations absorb UVL between 280 and 320 nm. This acid will stain white fabrics, especially cotton. The esters of PABA are slightly less effective and do not stain as much. Cross-sensitization can occur with some sunscreens. In particular, PABA and its derivatives may cross-react with sulfonamides, benzocaine, procaine, paraphenylenediamine, and azo dyes. Padimate-O, the ester form of PABA, is also used for UVB protection.

Definition

ChEBI: An aminobenzoic acid in which the amino group is para to the carboxy group.

brand name

RVPaba Lipstick (ICN).

General Description

Colorless crystals that discolor on exposure to light and air.

Reactivity Profile

4-Aminobenzoic acid is incompatible with ferric salts and oxidizing agents.

Hazard

Questionable carcinogen.

Safety Profile

Moderately toxic by ingestion and intravenous routes. Ingesting large doses can cause nausea, vomiting, skin rash, methemoglobinemia, and possibly toxic hepatitis. Experimental reproductive effects. Mutation data reported. Questionable carcinogen. Combustible. When heated to decomposition it emits toxic fumes of NO,. A topical sunscreen.

Purification Methods

Purify p-aminobenzoic acid by dissolving it in 4-5% aqueous HCl at 50-60o, decolorising with charcoal and carefully precipitating it with 30% Na2CO3 to pH 3.5-4 in the presence of ascorbic acid. It can be recrystallised from water, EtOH or EtOH/water mixtures. [Beilstein 14 IV 1126.]

More
Less

4-Aminobenzoic acidSupplierMore

Changzhou Sunlight Pharmaceutical Co., Ltd Gold
Tel:
0519-83131668
Email:
info@sunlightchem.com;info@sunlightchem.com
Changzhou Sunlight Farmacéutica.S.L. Gold
Tel:
13706121722
Email:
810308@sunlightchem.com;
HENGSHUI HAOYE CHEMICAL CO.,LTD. Gold
Tel:
18632882519 0318-2102300-
Email:
hy@chemcoms.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
Tel:
400-620-6333 021-20337333-801
Email:
market@aladdin-e.com
Guangzhou Helong Trading Co., Ltd. Gold
Tel:
18676882001
Email:
1162637465@qq.com
Basic information Safety Related Supplier