4-Aminobenzoic acid Chemical Properties
- Melting point:
- 187-189 °C(lit.)
- Boiling point:
- 251.96°C (rough estimate)
- 1.374 g/mL at 25 °C(lit.)
- refractive index
- 1.5323 (estimate)
- Flash point:
- 250 °C
- storage temp.
- 95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow
- Crystalline Powder
- 2.50, 4.87(at 25℃)
- White to light yellow
- 3.5 (5g/l, H2O, 20℃)
- PH Range
- Water Solubility
- 4.7 g/L (20 ºC)
- Air & Light Sensitive
- Stable. Incompatible with strong oxidizing agents. Combustible. Sensitive to light and air. May discolour on exposure to light.
- CAS DataBase Reference
- 150-13-0(CAS DataBase Reference)
- NIST Chemistry Reference
- p-Aminobenzoic acid(150-13-0)
- EPA Substance Registry System
- p-Aminobenzoic acid (150-13-0)
- Hazard Codes
- Risk Statements
- Safety Statements
- WGK Germany
- HS Code
- Hazardous Substances Data
- 150-13-0(Hazardous Substances Data)
- LD50 in mice, rats (g/kg): 2.85, >6.0 orally (Scott, Robbins); LD50 in rabbits (g/kg): 2.0 i.v. (Richards); 1.83 orally (Cronheim)
4-Aminobenzoic acid Usage And Synthesis
4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position) is an organic compound with the formula H2NC6H4CO2H. PABA is a white solid, although commercial samples can appear gray. It is slightly soluble in water. It consists of a benzene ring substituted with amino and a carboxyl groups. The compound occurs naturally. The potassium salt is used as a drug against fibrotic skin disorders, such as Peyronie's disease, under the trade name Potaba. PABA is also occasionally used in pill form by sufferers of irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels.
White to off white crystalline powder
Widely distributed in nature as a B complex factor. Baker’s yeast contains 5 to 6 ppm, brewer’s yeast from 10 to 100 ppm. Occurs free and in ester form.
gastric acid secretion inhibitor
octyl dimethyl PABA (padimate-O; p-aminobenzoic acid) is an FDA-approved sunscreen chemical whose InCI name is now ethylhexyl dimethyl PABA.
PABA is a sunscreen chemical with an approved usage level of 5 to 15 percent. It is found to be irritating to sensitive skin, has the potential to cause sensitization, and is considered too water soluble. once extremely popular, this ingredient has practically disappeared from sunscreen formulations. PABA is a yellowish or colorless acid found in vitamin B complex.
PABA preparations absorb UVL between 280 and 320 nm. This acid will stain white fabrics, especially cotton. The esters of PABA are slightly less effective and do not stain as much. Cross-sensitization can occur with some sunscreens. In particular, PABA and its derivatives may cross-react with sulfonamides, benzocaine, procaine, paraphenylenediamine, and azo dyes. Padimate-O, the ester form of PABA, is also used for UVB protection.
ChEBI: An aminobenzoic acid in which the amino group is para to the carboxy group.
RVPaba Lipstick (ICN).
Colorless crystals that discolor on exposure to light and air.
4-Aminobenzoic acid is incompatible with ferric salts and oxidizing agents.
Moderately toxic by ingestion and intravenous routes. Ingesting large doses can cause nausea, vomiting, skin rash, methemoglobinemia, and possibly toxic hepatitis. Experimental reproductive effects. Mutation data reported. Questionable carcinogen. Combustible. When heated to decomposition it emits toxic fumes of NO,. A topical sunscreen.
Purify p-aminobenzoic acid by dissolving it in 4-5% aqueous HCl at 50-60o, decolorising with charcoal and carefully precipitating it with 30% Na2CO3 to pH 3.5-4 in the presence of ascorbic acid. It can be recrystallised from water, EtOH or EtOH/water mixtures. [Beilstein 14 IV 1126.]
4-Aminobenzoic acid Preparation Products And Raw materials
- P-AMINOBENZOIC ACID ETHYL ESTER,P-AMINOBENZOIC ACID ETHYL ESTER
- p-Nitrobenzoic acid
- Tris Base
- Stearic acid
- 4-Aminobenzoic acid
- Citric acid
- Methyl 4-aminobenzoate
- 6-Aminocaproic acid
- Methyl anthranilate
- Ethyl 2-(Chlorosulfonyl)acetate
- O-AMINOBENZOIC ACID,O-AMINOBENZOIC ACID
- tert-Butyl 4-aminobenzoate
- 4-Amino-benzenesulfonic acid monosodium salt
- P-AMINOBENZOIC ACID BUTYL ESTER,P-AMINOBENZOIC ACID BUTYL ESTER
- Sulfanilic acid
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