NIGERICIN SODIUM SALT

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NIGERICIN SODIUM SALT Basic information

Product Name:
NIGERICIN SODIUM SALT
CAS:
28380-24-7
MF:
C40H67NaO11
MW:
746.94
Mol File:
28380-24-7.mol
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NIGERICIN SODIUM SALT Chemical Properties

Melting point:
183.5-185°
alpha 
D24 +36.2° (c = 0.842 in CHCl3)
Boiling point:
779.9±60.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
chloroform: 10 mg/mL, clear, colorless
pka
4.39±0.10(Predicted)
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Safety Information

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 3462 6.1/PG 3
WGK Germany 
3
RTECS 
QT6840000
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29419090
Toxicity
LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)

MSDS

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NIGERICIN SODIUM SALT Usage And Synthesis

Uses

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Definition

ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.

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NIGERICIN SODIUM SALTSupplierMore

Fujian Kerui Pharmaceutical Co., Ltd. Gold
Tel:
18505919179 15960103919
Email:
23115188@qq.com
Raw material medicin reagent co.,Ltd Gold
Tel:
025-57798860
Email:
sales@njromanme.com
Shanghai Boyle Chemical Co., Ltd.
Tel:
Email:
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel:
400-666-7788 010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Chemsky(shanghai)International Co.,Ltd.
Tel:
021-50135380
Email:
shchemsky@sina.com
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