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Peroxyacetic acid

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Peroxyacetic acid Basic information

Product Name:
Peroxyacetic acid
CAS:
79-21-0
MF:
C2H4O3
MW:
76.05
EINECS:
201-186-8
Mol File:
79-21-0.mol
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Peroxyacetic acid Chemical Properties

Melting point:
-44 °C
Boiling point:
105 °C
Density 
1.19 g/mL at 20 °C
vapor pressure 
Low
refractive index 
n20/D 1.391
Flash point:
41 °C
storage temp. 
2-8°C
pka
8.2(at 25℃)
color 
Colorless liquid
Odor
Acrid odor
Water Solubility 
soluble, >=10 g/100 mL at 19 ºC
Merck 
13,7229
BRN 
1098464
Stability:
Unstable - may explode on heating. May react violently with organic materials. Incompatible with strong oxidizing agents, acetic anhydride, alkenes, organics.
CAS DataBase Reference
79-21-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethaneperoxoic acid(79-21-0)
EPA Substance Registry System
Peracetic acid (79-21-0)
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Safety Information

Hazard Codes 
O,C,N
Risk Statements 
7-20/21/22-35-50-10-34-22-20
Safety Statements 
26-36/37/39-45-61-3/7-23-14A-14-60-9-7-3
RIDADR 
UN 3109 5.2
WGK Germany 
2
RTECS 
SD8750000
4.4-8
Autoignition Temperature
Explodes when heated to 110 °C
HazardClass 
5.2
PackingGroup 
II
HS Code 
29159000
Hazardous Substances Data
79-21-0(Hazardous Substances Data)
Toxicity
LD50 (mg/kg) in rats: 1540 orally; in rabbits: 1410 dermally; LC50 in rats (mg/m3): 450 by inhalation (Klopotek)

MSDS

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Peroxyacetic acid Usage And Synthesis

Chemical Properties

colourless liquid with an acrid odour

Uses

Environmentally friendly biocide; disinfectant in the food and beverage industry; bleaching agent for textiles and paper. Oxidizing agent in organic synthesis.

Uses

Peroxyacetic acid is used as an epoxidizingagent, for bleaching, as a germicide and fungicide, and in the synthesis of pharmaceuticals.Its solution Dialox is used as a cleansing andsterilizing agent in the reuse of highly permeable dialyzers. Turcic et al. (1997) have reported the efficacy of peroxyacetic acid asa local antiseptic in healing war wounds.Oxidative degradation of polynuclear aromatic hydrocarbons by peroxy acid in contaminated soils has been effectively achieved(N’Guessan et al. 2004).

Production Methods

Peracetic acid (PAA) is a mixture of acetic acid (CH3COOH) and hydrogen peroxide (H2O2) in an aqueous solution. It is a very strong oxidizing agent and has stronger oxidation potential than chlorine or chlorine dioxide. Liquid, clear, and colorless with no foaming capability. It has a strong pungent acetic acid odor, and the pH is acid . Peracetic acid is produced by reacting acetic acid and hydrogen peroxide. The reaction is allowed to continue for up to 10 days in order to achieve high yields of product. Additional methods of preparation involve the oxidation of acetaldehyde or alternatively as an end product of the reaction of acetic anhydride, hydrogen peroxide, and sulfuric acid. Another method involves the reaction of tetraacetylethylenediamine (TAED) in the presence of an alkaline hydrogen peroxide solution.

General Description

Colorless liquid with a strong, pungent acrid odor. Used as a bactericide and fungicide, especially in food processing; as a reagent in making caprolactam and glycerol; as an oxidant for preparing epoxy compounds; as a bleaching agent; a sterilizing agent; and as a polymerization catalyst for polyester resins.

Air & Water Reactions

Soluble in water

Reactivity Profile

Self-reactive. Peracids should be handled only in small quantities and with extreme care when pure or very concentrated. Organic peracids, such as Peroxyacetic acid, are so unstable that they may explode during distillation, even under reduced pressure [NFPA 1991].

Health Hazard

This is a very toxic compound. The probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150 pound person.

Health Hazard

Peroxyacetic acid is a severe irritant to theskin and eyes. It can cause severe acid burns.Irritation from 1 mg was severe on rabbits’eyes. Its toxicity is low. The toxicologicalroutes of entry to the body are inhalation,ingestion, and skin contact. The toxicity dataare as follows (NIOSH 1986):LC50 inhalation (rats): 450 mg/m3
LD50 oral (mice): 210 mg/kg
LD50 oral (guinea pigs): 10 mg/kg
Its toxicity in humans should be very low,and a health hazard may arise only fromits severe irritant action. Studies on miceshowed that it caused skin tumors at the siteof application. Its carcinogenicity on humansis not reported. No exposure limit is set forperoxyacetic acid in air.

Health Hazard

The acute toxicity of peracetic acid is low. However, peracids are extremely irritating to the skin, eyes, and respiratory tract. Skin or eye contact with the 40% solution in acetic acid can cause serious burns. Inhalation of high concentrations of mists of peracetic acid solutions can lead to burning sensations, coughing, wheezing, and shortness of breath.
Peracetic acid has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans. There is some evidence that this compound is a weak carcinogen from animal studies (mice).
Data on other peracids suggest peracetic acid may show the worst chronic and acute toxicity of this class of compounds. Other commonly available peracids, such as perbenzoic acid and m-chloroperbenzoic acid (MCPBA) are less toxic, less volatile, and more easily handled than the parent substance.

Fire Hazard

Peracetic acid explodes when heated to 110 °C, and the pure compound is extremely shock sensitive. Virtually all peracids are strong oxidizing agents and decompose explosively on heating. Moreover, most peracids are highly flammable and can accelerate the combustion of other flammable materials if present in a fire. Fires involving peracetic acid can be fought with water, dry chemical, or halon extinguishers. Containers of peracetic acid heated in a fire may explode.

Fire Hazard

Decomposes violently at 230F. When heated to decomposition, Peroxyacetic acid emits acrid smoke and fumes. Runoff to sewer may create a fire or explosion hazard. Powerful oxidizer. Isolate from other stored material, particularly accelerators, oxidizers, and organic or flammable materials. Avoid shock and heat. Hazardous polymerization may not occur.

Flammability and Explosibility

Peracetic acid explodes when heated to 110 °C, and the pure compound is extremely shock sensitive. Virtually all peracids are strong oxidizing agents and decompose explosively on heating. Moreover, most peracids are highly flammable and can accelerate the combustion of other flammable materials if present in a fire. Fires involving peracetic acid can be fought with water, dry chemical, or halon extinguishers. Containers of peracetic acid heated in a fire may explode.

Agricultural Uses

Fungicide, Herbicide, Nematicide, Rodenticide, Microbiocide: This compound is used as bactericide and fungicide, especially in food processing, a reagent in making caprolactam and glycerol; an oxidant for preparing epoxy compounds; a bleaching agent; a sterilizing agent; and a polymerization catalyst for polyester resins. Not approved for use in EU countries. Registered for use in the U.S. and Canada.

Trade name

DESOXON 1®; ESTOSTERIL®; OSBON AC®; OXYMASTER®; PROXITANE®

Safety Profile

Poison by ingestion. Moderately toxic by inhalation and skin contact. A corrosive eye, sktn, and mucous membrane irritant. Questionable carcinogen with experimental tumorigenic data by skin contact. Flammable liquid. Severe explosion hazard when exposed to heat or by spontaneous chemical reaction. Explodes violently at 1 10°C. A powerful oxidizing agent. Explosive reaction with acetic anhydride, 5-p-chlorophenyl-2,2-dimethyl-3hexanone. Violent reaction with ether solvents (e.g., tetrahydrofuran, diethyl ether), metal chloride solutions (e.g., calcium chloride, potassium chloride, sodium chloride), olefins, organic matter. Dangerous; keep away from combustible materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fire, use water, foam, CO2. Used as a polymerization initiator, curing agent, and cross-linhng agent. See also PEROXIDES, ORGANIC.

storage

Reactions involving large quantities of peracids should be carried out behind a safety shield. Peracetic acid should be used only in areas free of ignition sources and should be stored in tightly sealed containers in areas separate from oxidizable compounds and flammable substances. Other commonly available peracids, such as perbenzoic acid and m-chloroperbenzoic acid (MCPBA), are less toxic, less volatile, and more easily handled than peracetic acid.

Incompatibilities

Peracids such as peracetic acid are strong oxidizing agents and react exothermically with easily oxidized substrates. In some cases the heat of reaction can be sufficient to induce ignition, at which point combustion is accelerated by the presence of the peracid. Violent reactions may potentially occur, for example, with ethers, metal chloride solutions, olefins, and some alcohols and ketones. Shock-sensitive peroxides may be generated by the action of peracids on these substances as well as on carboxylic anhydrides. Some metal ions, including iron, copper, cobalt, chromium, and manganese, may cause runaway peroxide decomposition. Peracetic acid is also reportedly sensitive to light.

Waste Disposal

Excess peracetic acid and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines. Peracids may be incompatible with other flammable mixed chemical waste; for example, shock-sensitive peroxides can be generated by reaction with some ethers such as THF and diethyl ether.

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