3-METHYLCHOLANTHRENE Chemical Properties
- Melting point:
- 178-180 °C(lit.)
- Boiling point:
- 280 °C80 mm Hg(lit.)
- 1.28 g/cm3 (20℃)
- refractive index
- 1.4664 (estimate)
- Flash point:
- -5 °C
- storage temp.
- Water Solubility
- 2.9ug/L(25 ºC)
- Stable. Combustible. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 56-49-5(CAS DataBase Reference)
- EPA Substance Registry System
- 3-Methylcholanthrene (56-49-5)
3-METHYLCHOLANTHRENE Usage And Synthesis
Yellow Crystalline Solid
The term “coal tar products,” as used by NIOSH, includes coal tar and two of the fractionation products of coal tar, creosote and coal tar pitch, derived from the carbonization of bituminous coal. Coal tar, coal tar pitch, and creosote (coal tar creosote 8001-58-9) derived from bituminous coal often contain identifiable components which by themselves are carcinogenic, such as benzo(a) pyrene, benzanthracene, chrysene, and phenanthrene. Other chemicals from coal tar products, such as anthracene, carbazole, fluoranthene, and pyrene may also cause cancer,but these causal relationships have not been adequately documented. Also, the research chemical methylcholanthrene (CAS: 56-49-5), a powerful carcinogen, fits this category. Coal tar pitch is a black viscous liquid. Aromatic solvent odor. Boiling point =>260°C; specific gravity (H2O:1) = 1.07-108; freezing/melting point = 250-°180C;flash point = 207°C (coal tar pitch); 74C (creosote oil);autoignition temperature =>510°C. Insoluble in water.Coal tar creosote (8001-58-9, crosote) is an black oily,tar-like substance. Pungent odor
3-Methylcholanthrene is a solid that crystallizes from benzene and ether as pale yellow prisms. 3-methylcholanthrene is insoluble in water and soluble in alcohol. It is combustible, and can react with oxidizing materials.
ChEBI: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Yellow crystals or solid.
Air & Water Reactions
Insoluble in water.
3-METHYLCHOLANTHRENE can react with oxidizing materials. Ozone and chlorinating agents oxidize 3-METHYLCHOLANTHRENE.
Flash point data for 3-METHYLCHOLANTHRENE are not available; however, 3-METHYLCHOLANTHRENE is probably combustible.
Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
The coke-oven plant is the principal source of coal tar. The hot gases and vapors produced during the conversion of coal to coke are collected by means of a scrubber, which condenses the effluent into ammonia, water, crude tar, and other by-products. Crude tar is separated from the remainder of the condensate for refining and may undergo further processing. Employees may be exposed to pitch and creosote in metal and foundry operations; when installing electrical equipment; in construction, railway, utility; and briquette manufacturing.
3-Methylcholanthrene is a rapid, all-around neoplastic agent and a potent liver tumorigen.
UN1136 Coal tar distillates, flammable, Hazard Class: 3; Labels: 3-Flammable liquid
Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Phenols, such as creosote react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Flammable hydrogen gas is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
- 3-METHYLCHOLANTHRENE SOLUTION 100UG/ML IN TOLUENE 5X1ML
- Benz(j)aceanthrylene, 1,2-dihydro-2-fluoro-3-methyl-
- 3-METHYLCHOLANTHRENE, [3H]-
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