THIOFLAVINE S

Product NameTHIOFLAVINE S
CAS1326-12-1
MFNULL
MW0
EINECS215-418-0
MOL FileMol File

Chemical Properties

storage temp.	Amber Vial, -20°C Freezer, Under inert atmosphere
solubility	ethanol: water (1:1): soluble1mg/mL
form	powder
Colour Index	49010
color	Dark Red to Very Dark Brown
Stability	Light Sensitive
EPA Substance Registry System	C.I. Direct Yellow 7 (1326-12-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

Thioflavine S is a reagent also known as Direct Yellow 7; potentially useful as an amyloid plaque stain. Dyes and metabolites.

Preparation

(a) primrose spirit alkali (C.I.Direct Yellow 59, C.I. 49000) methylation, then will be preparing sulphonated product (GP 1251738); (b) primrose spirit alkali stlfonation, then will product methylation (GP 53333).

Definition

ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation.

Properties and Applications

green light yellow. For golden is soluble in water, but soluble in ethanol as a green fluorescent yellow. The strong sulfuric acid in nearly colorless, with blue fluorescence, after diluted orange yellow precipitation. Used for cellulose fiber, wool, silk dyeing, silk printing, also can be used for leather color. Exhaust dyeing, good levelness.

Standard	Acid Resistance	Alkali Resistance	Light Fastness	Soaping		Water
Standard	Acid Resistance	Alkali Resistance	Light Fastness	Fading	Stain	Fading	Stain
ISO	2-3	4	1	1-2		2
AATCC	3	2	1	2		2