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Glycolonitrile

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Glycolonitrile Basic information

Product Name:
Glycolonitrile
CAS:
107-16-4
MF:
C2H3NO
MW:
57.05
EINECS:
203-469-1
Mol File:
107-16-4.mol
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Glycolonitrile Chemical Properties

Melting point:
-72°C
Boiling point:
183°C
Density 
1.076 g/mL at 20 °C
refractive index 
n20/D 1.389
Flash point:
133 °F
pka
11.31±0.10(Predicted)
Water Solubility 
>=10 g/100 mL at 20 ºC
Stability:
Stable, but may react violently with alkalies. Incompatible with strong oxidizing agents.
CAS DataBase Reference
107-16-4(CAS DataBase Reference)
NIST Chemistry Reference
Acetonitrile, hydroxy-(107-16-4)
EPA Substance Registry System
Formaldehyde cyanohydrin (107-16-4)
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
36/37/39-45-36/37-28
RIDADR 
UN 3276 6.1/PG 1
WGK Germany 
-
RTECS 
AM0350000
HazardClass 
6.1(a)
PackingGroup 
I
Hazardous Substances Data
107-16-4(Hazardous Substances Data)

MSDS

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Glycolonitrile Usage And Synthesis

Chemical Properties

light yellow liquid (typically available as a concentrated

Chemical Properties

Formaldehyde cyanohydrin is a colorless, odorless, oily liquid. Sweet taste (very highly toxic; do not test).

Uses

Solvent and organic intermediate.

Production Methods

Glycolonitrile is the result of reaction between formaldehyde and aqueous sodium cyanide in the presence of mineral acid.

General Description

Odorless colorless oil with a sweetish taste. Used in the manufacture of intermediates in pharmaceutical production, as a component of synthetic resins, as a chemical intermediate for organic compounds, and as a solvent.

Air & Water Reactions

Water soluble.

Reactivity Profile

Glycolonitrile may undergo spontaneous and violent decomposition. Traces of alkali (base) promote violent polymerization [Lewis].

Hazard

Toxic by ingestion, inhalation, and skin absorption.

Health Hazard

Extremely toxic, exposure by any route should be avoided; may have fatal consequences; death from asphyxiation may occur similar to that resulting from hydrogen cyanide.

Fire Hazard

Moderate explosion hazard when exposed to heat or by spontaneous chemical reaction in the presence of alkalies if uninhibited. When heated to decomposition, Glycolonitrile emits highly toxic fumes of cyanide and nitrogen oxides. Unstable, may explode on standing. Hazardous polymerization may occur. avoid the presence of alkalis, and exposure to heat.

Potential Exposure

Formaldehyde cyanohydrin is used in the manufacture of intermediates in pharmaceutical produc tion and as a component of synthetic resins as a chemical intermediate for organic compounds, and as a solvent.

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5). UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and exposure to heat. Unless stabilized with a weak acid solution, traces of alka lis may cause violent polymerization.

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