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2-Methoxyethanol

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2-Methoxyethanol Basic information

Product Name:
2-Methoxyethanol
CAS:
109-86-4
MF:
C3H8O2
MW:
76.09
EINECS:
231-791-2
Mol File:
109-86-4.mol
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2-Methoxyethanol Chemical Properties

Melting point:
-85 °C
Boiling point:
124-125 °C(lit.)
Density 
0.965 g/mL at 25 °C(lit.)
vapor density 
2.62 (vs air)
vapor pressure 
6.17 mm Hg ( 20 °C)
refractive index 
n20/D 1.402(lit.)
Flash point:
115 °F
storage temp. 
5°C
solubility 
Very soluble in acetone, dimethylsulfoxide, and 95% ethanol (quoted, Keith and Walters, 1992).
Miscible with N,N-dimethylformamide, ether, and glycerol (Windholz et al., 1983).
pka
15.7(at 25℃)
form 
Liquid
color 
green cap
Relative polarity
1
Odor
Mild ethereal.
PH Range
5- 7 at 25 °C
explosive limit
2.5-20%(V)
Water Solubility 
SOLUBLE
λmax
λ: 213 nm Amax: 1.00
λ: 240 nm Amax: 0.20
λ: 260 nm Amax: 0.05
λ: 300-400 nm Amax: 0.01
Merck 
14,6038
BRN 
1731074
Henry's Law Constant
(x 10-2 atm?m3/mol): 4.41, 3.63, 11.6, 3.09, and 3.813 at 10, 15, 20, 25, and 30 °C, respectively (EPICS, Ashworth et al., 1988)
Exposure limits
TLV-TWA skin 5 ppm (15.5 mg/m3) (ACGIH), 25 ppm (77.5 mg/m3) (OSHA).
Stability:
Stable, but contact with air may lead to the formation of explosive peroxides. A peroxide test should be carried out before this material is used if it has been exposed to air for some time, especially if it is to be purified by distillation. Contact with strong oxidizing agents may cause fire or explosion. Incompatible with strong bases, ac
InChIKey
XNWFRZJHXBZDAG-UHFFFAOYSA-N
CAS DataBase Reference
109-86-4(CAS DataBase Reference)
NIST Chemistry Reference
Ethanol, 2-methoxy-(109-86-4)
EPA Substance Registry System
2-Methoxyethanol (109-86-4)
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Safety Information

Hazard Codes 
T,F,C
Risk Statements 
60-61-10-20/21/22-39/23/24/25-23/24/25-11-35-34-36/38
Safety Statements 
53-45-36/37-16-26-23-36/37/39
RIDADR 
UN 1188 3/PG 3
WGK Germany 
3
RTECS 
ZC0110000
10
Autoignition Temperature
548 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29332990
Hazardous Substances Data
109-86-4(Hazardous Substances Data)
Toxicity
LD50 in rats, guinea pigs (mg/kg): 2460, 950 orally (Smyth); LC50 (7 hr in air) in mice: 4.6 mg/l (Werner)

MSDS

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2-Methoxyethanol Usage And Synthesis

Chemical Properties

2-Methoxyethanol is a colorless liquid with a slight ethereal odor. The Odor Threshold is 0.92.3 ppm. It is miscible with water and with aliphatic and aromatic hydrocarbons. It is a solvent for essential oils, lignin, dammar, Elemi Essential Oil, ester gum, kauri, mastic, rosin, sandarac resin, shellac, Zanzibar, nitrocellulose, cellulose acetate, alcohol-soluble dyes and many synthetic resins. Its solvency far cellulose esters is augmented when a ketone or a halogenated hydrocarbon i s added. The uses for 2-Methoxyethanol are as a solvent in quick-drying varnishes and enamels, in conjunction with aliphatic, aromatic and halogenated hydrocarbons, alcohols and ketones; in solvent mixtures and thinners for lacquers and dopes; in the manufacture of synthetic resin plasticizers and as a penetrating and leveling agent in dyeing processes, especially in the dyeing of leather, animal and vegetable fibers. Other uses are as o fixative in perfumes and as a solvent in odorless nail-polish lacquers. 2-Methoxyethanol should not be added to nitrocellulose lacquers containing coumarone resins or ester gum because it will cause incompatibility between these substances.

Physical properties

Colorless liquid with a mild, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were <300 μg/m3 (<96 ppbv) and 700 μg/m3 (220 ppbv), respectively (Hellman and Small, 1974).

Uses

2-Methoxyethanol is considered a non-comedogenic raw material. It is used as a solvent in nail products and as a stabilizer in cosmetic emulsions. It is able to penetrate the skin and may cause skin irritation.

Uses

The primary use of 2-methoxyethanol is as asolvent for cellulose acetate, certain syntheticand natural resins, and dyes. Other applications are in jet fuel deicing, sealing moisture-proof cellophane, dyeing leather, and use innail polishes, varnishes, and enamels.

Uses

Solvent for low-viscosity cellulose acetate, natural resins, some synthetic resins and some alcohol-soluble dyes; in dyeing leather, sealing moistureproof cellophane; in nail polishes, quick-drying varnishes and enamels, wood stains. In modified Karl Fischer reagent: Peters, Jungnickel, Anal. Chem. 27, 450 (1955).

Definition

ChEBI: A hydroxyether that is ethanol substituted by a methoxy group at position 2.

General Description

A clear colorless liquid. Flash point of 110°F. Less dense than water. Vapors are heavier than air.

Air & Water Reactions

Flammable. Water soluble.

Reactivity Profile

2-Methoxyethanol is incompatible with oxygen and strong oxidizing agents. Contact with bases may result in decomposition. Incompatible with acid chlorides and acid anhydrides. . 2-Methoxyethanol forms explosive peroxides.

Hazard

Toxic by ingestion and inhalation. Moderate fire risk. Toxic by skin absorption. Questionable carcinogen.

Health Hazard

2-Methoxyethanol is a teratogen and a chronic inhalation toxicant. The target organs are blood, kidney,and the central nervous system. In addi tion to inhalation, the other routes of expo sure are absorption through the skin, and ingestion. Animal studies indicated that over-exposure to this compound produced anemia, hematuria, and damage to the testes.In humans, inhalation of EGME vapors cancause headache, drowsiness, weakness, irrita tion of the eyes, ataxia, and tremor. The acuteinhalation toxicity, however, is low and anytoxic effect may be felt at a concentration ofabout 25–30 ppm in air
The oral and dermal toxicities of thiscompound in test animals were found to belower than the inhalation toxicity. Ingestioncan produce an anesthetic effect and in alarge dosage can be fatal. An oral intake ofabout 200 mL may cause death to humans.
LC50 value (mice): 1480 ppm/7 h,
LD50 value (rabbits): 890 mg/kg
EGME is a teratogen exhibiting fetotoxi city, affecting the fertility and the litter size,and causing developmental abnormalities inthe urogenital and musculoskeletal systemsin test animals.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, inhalation, shin contact, intraperitoneal, and intravenous routes. Human systemic effects by inhalation: change in motor activity, tremors, and convulsions. Experimental teratogenic and reproductive effects. A skin and eye irritant. Mutation data reported. When used under conditions that do not require the application of heat, thts material probably presents little hazard to health. However, in the manufacture of fused collars which require pressing with a hot iron, cases have been reported showing disturbance of the hemopoietic system with or without neurologcal signs and symptoms. The blood picture may resemble that produced by exposure to benzene. Two cases reported had severe aplastic anemia with tremors and marked mental dullness. The persons affected had been exposed to vapors of methyl "Cellosolve," ethanol, methanol, ethyl acetate, and petroleum naphtha. flame. A moderate explosion hazard. Can react with oxidizing materials to form explosive peroxides. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS. Flammable liquid when exposed to heat or

Potential Exposure

2-Methoxyethanol is used as a jet fuel additive; solvent for protective coating; and in chemical synthesis. Ethylene glycol ethers are used as solvents for resins used in the electronics industry, lacquers, paints, varnishes, gum, perfume; dyes and inks; and as a constituent of painting pastes, cleaning compounds; liquid soaps; cosmetics, nitrocellulose, and hydraulic fluids.

Carcinogenicity

There are no experimental carcinogenicity or cancer epidemiology data relating to this chemical , but some short-term test data are available and are summarized in the section on genetic and related cellular effects.

Environmental Fate

Photolytic. Grosjean (1997) reported an atmospheric rate constant of 1.25 x 10-11 cm3/molecule?sec at 298 K for the reaction of methyl cellosolve and OH radicals. Based on an atmospheric OH concentration of 1.0 x 106 molecule/cm3, the reported half-life of methyl cellosolve is 0.64 d (Grosjean, 1997).
Chemical/Physical. At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 342 mg/L. The adsorbability of the carbon used was 132 mg/g carbon (Guisti et al., 1974).

Shipping

UN1188 Ethylene glycol monomethyl ether, Hazard Class: 3; Labels: 3-Flammable liquid

Purification Methods

Peroxides can be removed by refluxing with stannous chloride or by filtration under slight pressure through a column of activated alumina. 2-Methoxyethanol can be dried with K2CO3, CaSO4, MgSO4 or silica gel, then distilled from sodium. Aliphatic ketones (and water) can be removed by making the solvent 0.1% in 2,4-dinitrophenylhydrazine and allowing to stand overnight with silica gel before fractionally distilling. [Beilstein 1 IV 2375.]

Incompatibilities

Vapors may form explosive mixture with air. Heat or oxidizers may cause the formation of unstable peroxides. Attacks many metals. Strong oxidizers may cause fire and explosions. Strong bases cause decomposition and the formation of toxic gas. Attacks some plastics, rubber and coatings. May accumulate static electrical charges, and may cause ignition of its vapors.

Waste Disposal

Concentrated waste containing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.

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2-Methoxyethanol SupplierMore

Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
Tel:
021-20337333-801
Email:
market@aladdin-e.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
Alfa Aesar
Tel:
400-610-6006; 021-67582000
Email:
saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
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