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DIGITOXIN

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DIGITOXIN Basic information

Product Name:
DIGITOXIN
CAS:
71-63-6
MF:
C41H64O13
MW:
764.94
EINECS:
200-760-5
Mol File:
71-63-6.mol
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DIGITOXIN Chemical Properties

Melting point:
240 °C (dec.)(lit.)
alpha 
D20 +4.8° (c = 1.2 in dioxane)
Boiling point:
654.47°C (rough estimate)
Density 
1.0971 (rough estimate)
refractive index 
17 ° (C=2, CHCl3)
Flash point:
9℃
storage temp. 
Dark Room
solubility 
chloroform: soluble
pka
13.50±0.70(Predicted)
form 
powder
Water Solubility 
3.9mg/L(25 ºC)
Merck 
14,3163
BRN 
76678
EPA Substance Registry System
Digitoxin (71-63-6)
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Safety Information

Hazard Codes 
T,F
Risk Statements 
23/25-33-39/23/24/25-23/24/25-11
Safety Statements 
45-36/37-16
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
RTECS 
IH2275000
3-10
TSCA 
Yes
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2938900000
Toxicity
LD50 in guinea pigs, cats (mg/kg): 60.0, 0.18 orally (Foerster)

MSDS

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DIGITOXIN Usage And Synthesis

Chemical Properties

White Solid

Uses

inotropic, cardiotonic

brand name

Crystodigin (Lilly) .

General Description

Odorless white or pale buff microcrystalline powder. Used as a cardiotonic drug.

Health Hazard

Material is bioactive and capable of causing cardiac arrythmias and electrolyte imbalances that may be fatal. Death is due to ventricular fibrillation or cardiac standstill. Material has a high toxicity hazard rating; it may cause death or permanent injury after a very short exposure. It is classified as super toxic; an estimated single lethal dose is 3-10 mg.

Fire Hazard

When heated to decomposition, DIGITOXIN emits acrid smoke and irritating fumes.

Safety Profile

A deadly poison by most routes. Human systemic effects: arrhythmias, cardiomyopathy, EKG changes, nausea or vomiting, paresthesia, pulse rate increase, thrombocytopenia. Human reproductive effects by ingestion: reduced viability of newborn. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also DIGITALIS.

Purification Methods

Digitoxin crystallises from MeOH, aqueous EtOH with 0.5 to 1 H2O and from H2O as the dihydrate. It also crystallises from CHCl3/Et2O as anhydrous crystals. The hydrate dehydrates at 120o/vacuum. Its solubility is 2.5% in CHCl3, 1.7% in EtOH, 0.25% in EtOAc, and 0.001% in H2O; and has E1cm 202.5 at 219-220nm (50% EtOH). [Stoll et al. Helv Chim Acta 37 1134 1954, Demoen & Janssen J Am Pharm Assoc 42 635 1953, Beilstein 18 IV 1478.]

DIGITOXIN Preparation Products And Raw materials

Raw materials

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DIGITOXINSupplierMore

J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
LGM Pharma
Tel:
1-(800)-881-8210
Email:
inquiries@lgmpharma.com
Chemsky(shanghai)International Co.,Ltd.
Tel:
021-50135380
Email:
shchemsky@sina.com
Tianjin heowns Biochemical Technology Co., Ltd.
Tel:
400 638 7771
Email:
sales@heowns.com
Sinopharm Chemical Reagent Co,Ltd.
Tel:
86-21-63210123
Email:
sj_scrc@sinopharm.com
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