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THIOSTREPTON

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THIOSTREPTON Basic information

Product Name:
THIOSTREPTON
CAS:
1393-48-2
MF:
C72H85N19O18S5
MW:
1664.89
EINECS:
215-734-9
Mol File:
1393-48-2.mol
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THIOSTREPTON Chemical Properties

Melting point:
248-257°C (dec.)
alpha 
D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density 
1.0824 (rough estimate)
refractive index 
1.6700 (estimate)
storage temp. 
−20°C
solubility 
Soluble in DMSO or chloroform
form 
Off-white powder
pka
10.43±0.46(Predicted)
Water Solubility 
0.24g/L(28 ºC)
Merck 
13,9440
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
XN6300100
10-21
HS Code 
29419090
Toxicity
LD50 oral in mouse: > 1gm/kg

MSDS

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THIOSTREPTON Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

beta-adrenergic agonist

Uses

Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Uses

Natural antibiotic derived from Streptomyces.

Uses

A protein synthesis-inhibiting antibiotic

Definition

ChEBI: A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitu or agent.

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THIOSTREPTONSupplierMore

Lingyuan Bebiansen Biological Technology Co., Ltd Gold
Tel:
18642120371
Email:
2837458851@qq.com
J & K SCIENTIFIC LTD.
Tel:
400-666-7788 010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
18930552037 821-50328103-801
Email:
3bsc@sina.com
LGM Pharma
Tel:
1-(800)-881-8210
Email:
inquiries@lgmpharma.com
Chemsky(shanghai)International Co.,Ltd.
Tel:
021-50135380
Email:
shchemsky@sina.com
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