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2,3-Dichlorobenzoic acid

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2,3-Dichlorobenzoic acid Basic information

Product Name:
2,3-Dichlorobenzoic acid
CAS:
50-45-3
MF:
C7H4Cl2O2
MW:
191.01
EINECS:
200-039-5
Mol File:
50-45-3.mol
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2,3-Dichlorobenzoic acid Chemical Properties

Melting point:
168-170 °C(lit.)
Boiling point:
273.68°C (rough estimate)
Density 
1.4410 (rough estimate)
refractive index 
1.4590 (estimate)
form 
neat
Water Solubility 
slightly soluble
BRN 
1946217
InChIKey
QAOJBHRZQQDFHA-UHFFFAOYSA-N
CAS DataBase Reference
50-45-3(CAS DataBase Reference)
EPA Substance Registry System
2,3-Dichlorobenzoic acid (50-45-3)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36-24/25
WGK Germany 
2
RTECS 
DG6475000
HazardClass 
IRRITANT
HS Code 
29163990

MSDS

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2,3-Dichlorobenzoic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2,3-Dichlorobenzoic acid is the key intermediate for antiepileptic drug Lamotrigine (L173250) and other pharmaceuticals for the treatment of central nervous system (CNS) disorders and disease.

Purification Methods

Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008.] Crystallise the acid from H2O, aqueous EtOH, or 30% aqueous AcOH and several times from *C6H6, then dry it in vacuo at 40o overnight. The methyl ester has m 35-39o . [Hope & Riley J Chem Soc 123 2478 1923, Lock Monatsh Chem 90 687 1959, Shorter & Mather J Chem Soc 4744 1961, Beilstein 9 II 228, 9 IV 998.]

2,3-Dichlorobenzoic acid Preparation Products And Raw materials

Preparation Products

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Alfa Aesar Gold
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400-610-6006
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Shijiazhuang yaoBo Pharmaceutical Co., Ltd. Gold
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Giant chemicals Gold
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18108076537 028-85434334-
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J & K SCIENTIFIC LTD.
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400-666-7788 010-82848833-
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jkinfo@jkchemical.com;market6@jkchemical.com
future industrial shanghai co., ltd
Tel:
400-0066-400
Email:
sales@jonln.com;sales@jonln.com
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