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Tosylmethyl isocyanide

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Tosylmethyl isocyanide Basic information

Product Name:
Tosylmethyl isocyanide
CAS:
36635-61-7
MF:
C9H9NO2S
MW:
195.24
EINECS:
253-140-1
Mol File:
36635-61-7.mol
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Tosylmethyl isocyanide Chemical Properties

Melting point:
109-113 °C(lit.)
Density 
1.2721 (rough estimate)
refractive index 
1.5270 (estimate)
storage temp. 
-20°C
solubility 
water: slightly soluble
form 
Liquid
color 
Clear
Water Solubility 
insoluble
Sensitive 
Moisture Sensitive
Merck 
14,9556
BRN 
3592382
InChIKey
BBNNLJMGPASZPD-UHFFFAOYSA-N
CAS DataBase Reference
36635-61-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T,Xi
Risk Statements 
23/24/25
Safety Statements 
36/37-45-38-36/37/39-28A
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
21
Hazard Note 
Irritant
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29299000

MSDS

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Tosylmethyl isocyanide Usage And Synthesis

Chemical Properties

Pale yellow to light brown crystalline powder

Uses

Reagent for use in the preparation of biologically active pyrroles and imidazoles.1,2

Uses

Tosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.

Uses

Versatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.

Purification Methods

Use an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].

Tosylmethyl isocyanide Preparation Products And Raw materials

Preparation Products

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Tosylmethyl isocyanideSupplierMore

Synthetics China Co., Ltd. Gold
Tel:
0523-87980333-
Email:
jerry.yu@synthetics-china.com
Harbin kayMeiKe Chemical Co., Ltd. Gold
Tel:
1.39045187801394E+21
Email:
niulizhongnlz@126.com
Creasyn Finechem(Tianjin) Co., Ltd.
Tel:
022-1382037-2920
Email:
export@creasyn.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
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