ChemicalBook >  Product Catalog >  API >  Hormones and the Endocrine System >  Androgen and anabolic hormones >  Testosterone

Testosterone

Basic information Chemical Properties Indications and Uses Pharmacokinetics Application in Particular Diseases Safety Related Supplier

Testosterone Basic information

Product Name:
Testosterone
CAS:
58-22-0
MF:
C19H28O2
MW:
288.42
EINECS:
200-370-5
Mol File:
58-22-0.mol
More
Less

Testosterone Chemical Properties

Melting point:
152-156 °C
alpha 
101 º (c=1, dioxane 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
5 °C
storage temp. 
2-8°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble18.2 mg/ml
form 
powder
pka
15.06±0.60(Predicted)
Water Solubility 
22.79mg/L(20 ºC)
Merck 
13,9255
BRN 
1915399
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
MUMGGOZAMZWBJJ-DYKIIFRCSA-N
CAS DataBase Reference
58-22-0(CAS DataBase Reference)
NIST Chemistry Reference
Testosterone(58-22-0)
EPA Substance Registry System
Testosterone (58-22-0)
More
Less

Safety Information

Hazard Codes 
T,Xn,F
Risk Statements 
60-61-11-19-20-40-63-45-36-20/21/22-38
Safety Statements 
53-45-24/25-36/37-26-16
RIDADR 
UN 2252 3/PG 2
WGK Germany 
3
RTECS 
XA3030000
HS Code 
29372900
Hazardous Substances Data
58-22-0(Hazardous Substances Data)
Toxicity
LD50 oral in mammal (species unspecified): > 5gm/kg

MSDS

More
Less

Testosterone Usage And Synthesis

Chemical Properties

White crystalline powder with no aroma. Its melting point is 155℃, specific rotary power is [α]24D+109° (4%, ethanol), and its ethanol solution has the greatest absorbance at a wavelength of 240nm. It is easily soluble in ethanol (1:5), soluble in ether (1:100), and insoluble in water. LD50 (Large mice, venal transfusion) 326mg/kg. Studies show that it has latent carcinogenic effects on test animals.

Indications and Uses

Testosterone is the main natural male sex hormone in mammals and is a steroid hormone with 19 carbon atoms. It is the main male sex hormone secreted by the testes, and it is also the most active male sex hormone. It promotes humans’ and animals’ sex organ and secondary sex characteristic development, sperm maturation, and protein metabolism for muscle strengthening. Testosterone controls the growth and development of male sex organs and male secondary sex characteristics. It is mainly used in replacement therapy for eunuchism, treatment for male menopause syndrome, and treatment for impotence, and it is also used in biochemical research.

Pharmacokinetics

Testosterone can bind non-specifically with plasma albumins in blood, and it can also bind with plasma sex hormone binding globulins. It can be converted into estradiol and estrone in peripheral tissue. Testosterone is mostly degraded in the liver, where its A-ring is restored, and it is converted into 17- ketosteroid under the effects of 17β-Hydroxysteroid dehydrogenase. Along with androsterone, epiandrosterone, and etiocholanlone, it is combined with glucuronic acid or sulfate and excreted in urine. Most metabolites in urine that are excreted by binding to glucuronic acid belong to 17-ketosteroids.

Application in Particular Diseases

In Osteoporosis:

  • Testosterone replacement is not FDA approved for the prevention or treatment of osteoporosis. It should not be used solely for these indications but might be beneficial to reduce bone loss in patients needing therapy for hypogonadal symptoms. In a few studies, women receiving oral methyltestosterone 1.25 or 2.5 mg daily or testosterone implants 50 mg every 3 months had increased BMD. Various salt forms of testosterone were associated with increased BMD in some studies of hypogonadal men or senior men with normal hormone levels or mild hormonal deficiency. Transdermal gel, oral, intramuscular, and pellet testosterone products are available.
  • Patients using them should be evaluated within 1 to 2 months of initiation and then every 3 to 6 months thereafter.

Chemical Properties

white crystalline odourless solid

Uses

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Uses

androgen, antineoplastic

Uses

Testosterone, Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol. Testerone is a controlled substance (anabolic steroid). Androgen.

Uses

Rivastigmine metabolite

Uses

Secreted by the testis and is converted to dihydrotestosterone in the target tissue where is appears to mediate many of the biological actions of testosterone. CONTROLLED SUBSTANC

Definition

ChEBI: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-41C-5..

General Description

Testosterone, 17β-hydroxyandrost-4-en-3-one, is a naturally occurring androgen in men. Inwomen, it mainly serves as a biosynthetic precursor to estradiolbut also has other hormonal effects. It is rapidly metabolizedto relatively inactive 17-ones, however,preventing significant oral activity. Testosterone is availablein a transdermal delivery system (patch), a gel formulation, abuccal system, and as implantable pellets.

Hazard

A confirmed carcinogen.

Health Hazard

Controls secondary male sex characteristics Maintains functional competence of male reproductive ducts and glands
Increases protein anabolism; maintains spermatogenesis; inhibits follotropin
Increases male sex behavior; increases closure of epiphyseal plates

Biological Activity

Endogenous androgen receptor agonist.

Safety Profile

Confirmed carcinogen with experimental neoplastigenic and teratogenic data. Poison by intraperitoneal route. Human teratogenic effects by unspecified route: developmental abnormalities of the urogenital system. Experimental reproductive effects. Human mutation data reported. Workers engaged in manufacture and packagmg have shown effects from this hormone, e.g., enlargement of the breasts in male workers. A promoter. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a drug for the treatment of hypogonadism and metastatic breast cancer.

Purification Methods

Crystallise testosterone from aqueous acetone, hexane or isoPrOH. The long needles that separated from EtOH/AcOH were used for X-ray crystallography [Roberts et al. J Chem Soc Perkin Trans II 1978 1973.] The acetate [1045-69-8] crystallises from MeOH or aqueous Me2CO, with m 140-141o and [] D 20 +87.8o (c 1, EtOH). [Ruzicka et al. Helv Chim Acta 18 1478 1935 and 19 99, 842 1936, Beilstein 8 IV 974.]

Testosterone Preparation Products And Raw materials

Raw materials

More
Less

TestosteroneSupplierMore

Cheng Du Micxy Chemical Co.,Ltd Gold
Tel:
028-85632863-
Email:
sales@micxy.com;
Wuhan Magic Biological Technology Co., Ltd. Gold
Tel:
18872289958、027-52304252、QQ3400508168
Email:
3400508168@qq.com
Zhuhai JiaYi Biological Technology Co., Ltd. Gold
Tel:
18578209868 QQ2355327026
Email:
steroidbest@hotmail.com
Wuhan Shuangjin Fine Chemical Co., Ltd. Gold
Tel:
027-51903003-
Email:
773164315@qq.com;
卡托研究化学公司 Gold
Tel:
020-81215950- ;020-81215950-
Email:
customer@uwalab.com;customer@uwalab.com
Basic information Chemical Properties Indications and Uses Pharmacokinetics Application in Particular Diseases Safety Related Supplier