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Diclofenac sodium

Basic information Uses Mechanisms of action Clinical Application Safety Related Supplier

Diclofenac sodium Basic information

Product Name:
Diclofenac sodium
CAS:
15307-79-6
MF:
C14H10Cl2NNaO2
MW:
318.13
EINECS:
239-346-4
Mol File:
15307-79-6.mol
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Diclofenac sodium Chemical Properties

Melting point:
288-290°C
Density 
0.781 g/cm3
storage temp. 
-20°C Freezer
solubility 
H2O: 50 mg/mL
pka
4(at 25℃)
form 
White solid
Water Solubility 
Soluble in water to 50mg/ml.
Merck 
14,3081
Stability:
Stable.
InChIKey
KPHWPUGNDIVLNH-UHFFFAOYSA-M
CAS DataBase Reference
15307-79-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38-63
Safety Statements 
22-36/37-45-36-26-60-20
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
AG6330000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29224999
Toxicity
LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)

MSDS

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Diclofenac sodium Usage And Synthesis

Uses

Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain.

Mechanisms of action

Putative mechanisms of action of diclofenac may include inhibition of leukotriene synthesis, inhibition of phospholipase A2, modulation of free arachidonic acid levels, stimulation of adenosine triphosphate-sensitive potassium channels via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and centrally mediated and neuropathic mechanisms. Other emerging mechanisms of action may include inhibition of peroxisome proliferator activated receptor-c, reduction in plasma and synovial substance P and interleukin-6 levels, inhibition of the thromboxane-prostanoid receptor and inhibition of acid-sensing ion channels.

Clinical Application

Clinical trials have demonstrated the analgesic efficacy of diclofenac sodium in terms of relieving moderate to severe postoperative pain in patients undergoing dental surgery or minor orthopaedic surgery. Subcutaneous diclofenac sodium also effectively relieved moderate to severe neuropathic pain, related to cancer or not. Diclofenac sodium was generally well tolerated in clinical trials, with injection-site reactions among the most commonly reported adverse events.

Chemical Properties

Off-White Crystalline Solid

Uses

A nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.

Uses

An inhibitor of Cox-1 and Cox-2.

Uses

A nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor

Definition

ChEBI: The sodium salt of diclofenac.

brand name

Solaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene.

World Health Organization (WHO)

The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.

Veterinary Drugs and Treatments

The equine topical cream (Surpass?) is labeled for the control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints for use up to 10 days duration. While, theoretically, diclofenac could be used systemically (orally) in other veterinary species, there are approved and safer alternatives.

Diclofenac sodium Preparation Products And Raw materials

Raw materials

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Diclofenac sodiumSupplierMore

Beijing Yibai Biotechnology Co., Ltd. Gold
Tel:
Email:
shadow@yibaibiotech.com
WuHan YuanCheng Gongchuang Technology Co.Ltd Gold
Tel:
0531-85067660
Email:
gy08@yccreate.com
Wuhan HongxinKang Fine Chemical Co., Ltd. Gold
Tel:
027-59362599 18674037007
Email:
zhuoxingwc@163.com
Hubei Bangsun Chemical Co., Ltd. Gold
Tel:
18171081685
Email:
2834045742@qq.com
Wuhan Biocar Bio-Pharm Co., Ltd. Gold
Tel:
Email:
Albert@biocar.cn
Basic information Uses Mechanisms of action Clinical Application Safety Related Supplier