ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Sulfonates / Sulfinates salts >  Dansyl chloride

Dansyl chloride

Basic information Uses Safety Related Supplier

Dansyl chloride Basic information

Product Name:
Dansyl chloride
CAS:
605-65-2
MF:
C12H12ClNO2S
MW:
269.75
EINECS:
210-092-6
Mol File:
605-65-2.mol
More
Less

Dansyl chloride Chemical Properties

Melting point:
72-74 °C(lit.)
Boiling point:
371.3±22.0 °C(Predicted)
Density 
1.1702 (rough estimate)
refractive index 
1.5630 (estimate)
storage temp. 
2-8°C
solubility 
acetone: 50 mg/mL
pka
2.38±0.40(Predicted)
form 
powder and chunks
color 
yellow to orange
Water Solubility 
Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water.
Sensitive 
Moisture Sensitive
Merck 
14,2814
BRN 
2217205
InChIKey
XPDXVDYUQZHFPV-UHFFFAOYSA-N
CAS DataBase Reference
605-65-2(CAS DataBase Reference)
EPA Substance Registry System
1-Naphthalenesulfonyl chloride, 5-(dimethylamino)- (605-65-2)
More
Less

Safety Information

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-3
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
QK3688000
10-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29214980

MSDS

More
Less

Dansyl chloride Usage And Synthesis

Uses

Dansyl chloride or 5-Dimethylaminonaphthalene-1-sulfonyl chloride (CAS 605-65-2) is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.
Dansyl chloride is non-fluorescent until it reacts with amines. The resulting Dansyl amides have environmentally sensitive fluorescence quantum yields and emission maxima along with large Stokes shifts. This environment-sensitive fluorescence property has made Dansyl chloride an important tool for biophysical studies.

Chemical Properties

yellow to orange-yellow crystalline powder

Uses

Reagent for fluorescent labelling of amines, amino acids and proteins.

Uses

A fluorogenic reagent for N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

Uses

In fluorescent labelling, column chromatography, HPLC.

Safety Profile

Poison by intravenous route, When heated to decomposition it emits very toxic fumes of Cland NOx

More
Less

Dansyl chlorideSupplierMore

Bejing Famous Pharmaceutical Technology Co., Ltd. Gold
Tel:
;
Email:
1963319514@qq.com;famouszy@peking-pharmacy.com
TCI (Shanghai) Development Co., Ltd. Gold
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
Creative Peptides Gold
Tel:
Email:
info@creative-peptides.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
Basic information Uses Safety Related Supplier