Triethyl citrate Chemical Properties
- Melting point:
- -46 °C
- Boiling point:
- 294 °C
- 1.137 g/mL at 25 °C(lit.)
- vapor density
- 9.7 (vs air)
- vapor pressure
- 1 mm Hg ( 107 °C)
- 3083 | TRIETHYL CITRATE
- refractive index
- Flash point:
- >230 °F
- storage temp.
- H2O: soluble
- Water Solubility
- 5.7 g/100 mL (25 ºC)
- JECFA Number
- CAS DataBase Reference
- 77-93-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethyl citrate(77-93-0)
- EPA Substance Registry System
- Triethyl citrate (77-93-0)
Triethyl citrate Usage And Synthesis
Triethyl citrate is the triester of citric acid and ethyl alcohol.
Triethyl citrate is used as a flavoring agent in foods, as a high boiling solvent and plasticizer for vinyl resins and cellulose acetates, as a plasticizer in the pharmaceutical industry for coating. Triethyl citrate is used as a natural active ingredient and flavor component with excellent deodorizing and skin care properties in cosmetic and personal care products. Triethyl citrate is also used as a plasticizer and humectant for cigarette filters. Furthermore, triethyl citrate is used s a food additive for stabilizing foams, specifically as a whipping enhancer for organic egg whites during processing.
 RH Dave (2016) Overview of pharmaceutical excipients used in tablets and capsules, Drug Topics (online). Advanstar.
Triethyl citrate is odorless, but has a bitter taste.
Colorless, mobile liquid; bitter taste. Solubility in water 6.5 g/100 cc; solubility in oil 0.8 g/100 cc. Combustible.
Triethyl citrate is a clear, viscous, odorless, and practically colorless, hygroscopic liquid.
Reported found in Morello cherry, sour cherry and red currant. Also reported found in raw cabbage and white wine.
Pharmaceutic aid (plasticizer).
Triethyl Citrate is a sequestrant that is an oily liquid, slightly solu- ble in water. it is found in lemon drinks.
Triethyl citrate is prepared by the esterification of citric acid and ethanol in the presence of a catalyst.
By esterification of ethyl alcohol with citric acid.
Triethyl citrate and the related esters acetyltriethyl citrate, tributyl
citrate, and acetyltributyl citrate are used to plasticize polymers in
formulated pharmaceutical coatings. The coating applications
include capsules, tablets, beads, and granules for taste masking,
immediate release, sustained-release, and enteric formulations.
Triethyl citrate is also used as a direct food additive for flavoring, for solvency, and as a surface active agent.
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion and inhalation. Combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS and CITRIC ACID.
Triethyl citrate is used in oral pharmaceutical formulations and as a
direct food additive. It is generally regarded as a nontoxic and
nonirritant material. However, ingestion of large quantities may be
LD50 (mouse, IP): 1.75 g/kg
LD50 (rat, IP): 4 g/kg
LD50 (rat, oral): 5.9 g/kg
LD50 (rat, SC): 6.6 g/kg
Triethyl citrate should be stored in a closed container in a cool, dry location. When stored in accordance with these conditions, triethyl citrate is a stable product.
Triethyl citrate is incompatible with strong alkalis and oxidizing materials.
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Triethyl citrate Preparation Products And Raw materials
- Trihexyl O-acetylcitrate
- Triethyl citrate
- Mosapride citrate
- Triethyl phosphite
- Acetyl tributyl citrate
- ACETYL TRIETHYL CITRATE
- Calcium citrate
- Triethyl orthoformate
- Sodium citrate
- Triethyl methanetricarboxylate
- Triethyl phosphate
- CLOMIFENE CITRATE
- Ammonium citrate tribasic
- ARSENIC ACID TRIETHYL ESTER
- Zinc citrate
- Sildenafil citrate
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