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Triethyl citrate

Basic information Description References Safety Related Supplier

Triethyl citrate Basic information

Product Name:
Triethyl citrate
CAS:
77-93-0
MF:
C12H20O7
MW:
276.28
EINECS:
201-070-7
Mol File:
77-93-0.mol
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Triethyl citrate Chemical Properties

Melting point:
-46 °C
Boiling point:
294 °C
Density 
1.137 g/mL at 25 °C(lit.)
vapor density 
9.7 (vs air)
vapor pressure 
1 mm Hg ( 107 °C)
FEMA 
3083 | TRIETHYL CITRATE
refractive index 
n20/D 1.442(lit.)
Flash point:
>230 °F
storage temp. 
-20°C
solubility 
H2O: soluble
pka
11.57±0.29(Predicted)
form 
Liquid
color 
Clear
Odor
odorless
Water Solubility 
5.7 g/100 mL (25 ºC)
FreezingPoint 
-55℃
JECFA Number
629
Merck 
14,2326
BRN 
1801199
InChIKey
DOOTYTYQINUNNV-UHFFFAOYSA-N
CAS DataBase Reference
77-93-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl citrate(77-93-0)
EPA Substance Registry System
Triethyl citrate (77-93-0)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20
Safety Statements 
24/25-45
WGK Germany 
1
RTECS 
GE8050000
TSCA 
Yes
HS Code 
2918 15 00
Hazardous Substances Data
77-93-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 3200 mg/kg LD50 dermal Rabbit > 5000 mg/kg

MSDS

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Triethyl citrate Usage And Synthesis

Description

Triethyl citrate is the triester of citric acid and ethyl alcohol.
Triethyl citrate is used as a flavoring agent in foods, as a high boiling solvent and plasticizer for vinyl resins and cellulose acetates, as a plasticizer in the pharmaceutical industry for coating. Triethyl citrate is used as a natural active ingredient and flavor component with excellent deodorizing and skin care properties in cosmetic and personal care products. Triethyl citrate is also used as a plasticizer and humectant for cigarette filters. Furthermore, triethyl citrate is used s a food additive for stabilizing foams, specifically as a whipping enhancer for organic egg whites during processing.

References

[1] RH Dave (2016) Overview of pharmaceutical excipients used in tablets and capsules, Drug Topics (online). Advanstar.
[2] http://www.who.int/en/
[3] http://www.in-cosmetics.com
[4] http://www.chemicalland21.com
[5] https://www.ams.usda.gov/sites/default/files/media/Triethyl%20Citrate%20report%202014.pdf

Chemical Properties

Triethyl citrate is odorless, but has a bitter taste.

Chemical Properties

Colorless, mobile liquid; bitter taste. Solubility in water 6.5 g/100 cc; solubility in oil 0.8 g/100 cc. Combustible.

Chemical Properties

Triethyl citrate is a clear, viscous, odorless, and practically colorless, hygroscopic liquid.

Occurrence

Reported found in Morello cherry, sour cherry and red currant. Also reported found in raw cabbage and white wine.

Uses

Pharmaceutic aid (plasticizer).

Uses

Triethyl Citrate is a sequestrant that is an oily liquid, slightly solu- ble in water. it is found in lemon drinks.

Production Methods

Triethyl citrate is prepared by the esterification of citric acid and ethanol in the presence of a catalyst.

Preparation

By esterification of ethyl alcohol with citric acid.

Pharmaceutical Applications

Triethyl citrate and the related esters acetyltriethyl citrate, tributyl citrate, and acetyltributyl citrate are used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations.
Triethyl citrate is also used as a direct food additive for flavoring, for solvency, and as a surface active agent.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion and inhalation. Combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS and CITRIC ACID.

Safety

Triethyl citrate is used in oral pharmaceutical formulations and as a direct food additive. It is generally regarded as a nontoxic and nonirritant material. However, ingestion of large quantities may be harmful.
LD50 (mouse, IP): 1.75 g/kg
LD50 (rat, IP): 4 g/kg
LD50 (rat, oral): 5.9 g/kg
LD50 (rat, SC): 6.6 g/kg

storage

Triethyl citrate should be stored in a closed container in a cool, dry location. When stored in accordance with these conditions, triethyl citrate is a stable product.

Incompatibilities

Triethyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Triethyl citrate Preparation Products And Raw materials

Preparation Products

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Triethyl citrateSupplierMore

Hubei Hengluyuan Technology Co., Ltd. Gold
Tel:
18717196322
Email:
1764683941@qq.com;
J & K SCIENTIFIC LTD.
Tel:
400-666-7788 010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
400-660-8290 21-61259100-
Email:
sh@meryer.com
Alfa Aesar
Tel:
400-610-6006
Email:
saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
Basic information Description References Safety Related Supplier