Chloroacetaldehyde Chemical Properties
- Melting point:
- Boiling point:
- 80-100 °C(lit.)
- 1.236 g/mL at 25 °C
- vapor pressure
- 100 at 20 °C (NIOSH, 1997)
- refractive index
- Flash point:
- 128 °F
- Soluble in ether (Weast, 1986), acetone, and methanol (Hawley, 1981)
- Water Solubility
- soluble in acetone, methanol. Fully miscible in water.
- Air Sensitive
- Exposure limits
- Ceiling 3 mg/m3 (1 ppm) (ACGIH); IDLH.
- CAS DataBase Reference
- 107-20-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetaldehyde, chloro-(107-20-0)
- EPA Substance Registry System
- Chloroacetaldehyde (107-20-0)
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 2232 6.1/PG 1
- WGK Germany
- HS Code
- Hazardous Substances Data
- 107-20-0(Hazardous Substances Data)
- Acute oral LD50 for rats 75 mg/kg, mice 69 mg/kg (quoted, RTECS, 1985).
Chloroacetaldehyde Usage And Synthesis
Colorless transparent liquid
Chloroacetaldehyde is a combustible, colorless liquid with a very sharp, irritating odor.
Clear, colorless liquid with an irritating, acrid odor
Chloroacetaldehyde is used in the productionof 2-aminothiazole.
ChEBI: Acetaldehyde substituted at C-2 by chlorine.
A clear colorless liquid with a pungent odor. Flash point about 190°F. Corrosive to skin and mucous membranes. Chloroacetaldehyde is very toxic by inhalation.
Air & Water Reactions
Soluble in water. Forms an insoluble hemihydrate at greater than 50% concentration.
Chloroacetaldehyde polymerizes on standing. At greater than 50% concentration in water, Chloroacetaldehyde forms an insoluble hemihydrate. Sensitive to heat. Reacts with oxidizing agents. Incompatible with acids and water . Burns to give poisonous and irritating gases.
Corrosive to skin and mucous membranes. TLV: ceiling 1 ppm.
Chloroacetaldehyde is a highly toxic andcorrosive compound that can injure the eyes,skin, and respiratory system. Exposure toits vapor at high concentrations can producesevere irritation and impair vision. At lowconcentrations, the vapor can cause irritationand sore eyelids. Brief contact with 40%aqueous solution can result in skin burn anddestruction of tissues. A 0.5% dilute solutioncan still be irritating on skin.
Inhalation of its vapor at the 5-ppm levelcan irritate the eyes, nose, and throat. Ingestionmay result in pulmonary edema. Swallowinga concentrated solution may be fatal.The acute toxicity data are as follows:
LD50 value, intraperitoneal (rats): 2 mg/kg
LD50 value, oral (rats): 23 mg/kg
LD50 value, skin (rabbits): 67 mg/kg
This compound is a mutagen, testing positivein the Ames test.
Poisonous; may be fatal if inhaled, swallowed or absorbed through the skin. Overexposure causes intense irritation and edema of the eyes, mucous membranes, respiratory tract, and skin. Prolonged exposure causes tissue destruction, chemical burns and residual scarring. The eyes may experience permanent damage.
Combustible; flash point (closed cup) 87.8°C (190°F); flash point of 50% aqueous solution 53°C (128°F) (at this concentration it may form insoluble hemihydrate); it forms an explosive mixture with air. Reactions with strong acids and oxidizers are exothermic.
Suspected carcinogen. Poison by ingestion, skin contact, and intraperitoneal routes. Mutation data reported. Combustible when exposed to heat or flame. Reacts with oxidizing materials. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also ALDEHYDES and CHLORIDES.
Chloroacetaldehyde is used as a fungicide; as an intermediate in 2-aminothiazole manufacture; and in bark removal from tree trunks.
Chemical/Physical. Polymerizes on standing (Windholz et al., 1983).
UN22322-Chloroethanal, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, Inhalation Hazard Zone B.
Heat and water sensitive; concentrations of .50% form insoluble hemihydrate material on contact with water. Reacts with oxidizers, acids. On heating,chloroacetaldehyde releases chlorine fumes. Polymerizable upon standing
Incineration, preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced.
Chloroacetaldehyde Preparation Products And Raw materials
- Methyl trichloroacetate
- Chloroacetyl chloride
- Dichloroacetic acid methyl ester
- CHLORODIFLUOROACETIC ANHYDRIDE
- 2-CHLORO-2,2-DIPHENYLACETYL CHLORIDE
- Trichloroacetyl chloride
- Glyoxylic acid