ChemicalBook >  Product Catalog >  Organic Chemistry >  Heterocyclic Compounds >  2,4,6-Collidine

2,4,6-Collidine

Basic information Safety Related Supplier

2,4,6-Collidine Basic information

Product Name:
2,4,6-Collidine
CAS:
108-75-8
MF:
C8H11N
MW:
121.18
EINECS:
203-613-3
Mol File:
108-75-8.mol
More
Less

2,4,6-Collidine Chemical Properties

Melting point:
−43 °C(lit.)
Boiling point:
171-172 °C(lit.)
Density 
0.917 g/mL at 25 °C(lit.)
vapor pressure 
4 hPa (20 °C)
refractive index 
n20/D 1.498(lit.)
Flash point:
135 °F
storage temp. 
2-8°C
solubility 
35g/l
pka
7.43(at 25℃)
form 
Liquid
color 
Clear colorless to yellow
Water Solubility 
35 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,9718
BRN 
107283
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
108-75-8(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,4,6-trimethyl-(108-75-8)
EPA Substance Registry System
2,4,6-Trimethylpyridine (108-75-8)
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
10-20/21/22-36/37/38
Safety Statements 
26-36/37-36
RIDADR 
UN 1992 3/PG 3
WGK Germany 
3
RTECS 
UU0970000
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29333999
Hazardous Substances Data
108-75-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 400 mg/kg

MSDS

More
Less

2,4,6-Collidine Usage And Synthesis

Chemical Properties

colourless liquid

Uses

2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.

Definition

Methyl, ethyl, propyl, and trimethyl homologs of pyridine.

Hazard

Toxic.

Purification Methods

Commercial samples may be grossly impure. Likely contaminants include 3,5-dimethylpyridine, 2,3,6-trimethylpyridine and water. Brown, Johnson and Podall [J Am Chem Soc 76 5556 1954] fractionally distilled 2,4,6-trimethylpyridine under reduced pressure through a 40cm Vigreux column (p 11) and added to 430mL of the distillate slowly, with cooling to 0o, 45g of BF3-diethyl etherate. The mixture was again distilled, and an equal volume of dry *benzene was added to the distillate. Dry HCl was passed into the solution, which was kept cold in an ice-bath, and the hydrochloride was filtered off. It was recrystallised from absolute EtOH (1.5mL/g) to m 286-287o[m 256o(sealed tube), also m 293-294o subliming slowly]. The free base was regenerated by treatment with aqueous NaOH, then extracted with *benzene, dried (MgSO4) and distilled under reduced pressure. Sisler et al. [J Am Chem Soc 75 446 1953] precipitated trimethylpyridine as its phosphate from a solution of the base in MeOH by adding 85% H3PO4, shaking and cooling. The free base was regenerated as above. Garrett and Smythe [J Chem Soc 763 1903] purified the trimethylpyridine via the HgCl2 complex. It is more soluble in cold than hot H2O [the solubility is 20.8% at 6o, 3.5% at 20o, 1.8% at 100o]. Alternatively, purify it by dissolving it in CHCl3, adding solid K2CO3 and Drierite, filtering and fractionally distilling through an 8in helix-packed column. The sulfate has m 205o, and the picrate (from hot H2O) has m 155-156o. [Frank & Meikle J Am Chem Soc 72 4184 1950, Beilstein 20 H 250, 20 I 87, 20 II 164, 20 III/IV 2810, 20/6 V 93.]

More
Less

2,4,6-CollidineSupplierMore

Tocopharm Co., Ltd. Gold
Tel:
021-69895597- ;021-69895597- ;021-69895597-
Email:
info@tocopharm.com;sales@tocopharm.com;739486509@qq.com
Nanjing Apicci Pharmaceutical Technology Co., Ltd. Gold
Tel:
;
Email:
3590429773@qq.com;977144864@qq.com
Shanghai Qiao Chemical Science Co., Ltd Gold
Tel:
021-58892003- ;021-50396381
Email:
info@qiaochem.com;aaron@qiaochem.com;
Nanjing Kehua Chemical Technology Co., Ltd. Gold
Tel:
Email:
1551645678@qq.com
Shanghai Youde Chemical Technology Co., Ltd. Gold
Tel:
021-37910267
Email:
sales@udchem.com
Basic information Safety Related Supplier