Flufenamic acid
Flufenamic acid Basic information
- Product Name:
- Flufenamic acid
- CAS:
- 530-78-9
- MF:
- C14H10F3NO2
- MW:
- 281.23
- EINECS:
- 208-494-1
- Mol File:
- 530-78-9.mol
Flufenamic acid Chemical Properties
- Melting point:
- 132-135 °C(lit.)
- Boiling point:
- 373.9±42.0 °C(Predicted)
- Density
- 1.3380 (estimate)
- storage temp.
- Refrigerator
- form
- Crystalline Powder or Chunks
- pka
- pKa 3.9 (Uncertain);3.85 (Uncertain)
- color
- Off-white to gray-green
- Water Solubility
- 0.0265 g/L (37 ºC)
- Merck
- 14,4132
- BRN
- 1996069
- CAS DataBase Reference
- 530-78-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Flufenamic acid(530-78-9)
MSDS
- Language:EnglishProvider:Flufenamic acid
- Language:EnglishProvider:SigmaAldrich
- Language:EnglishProvider:ACROS
- Language:EnglishProvider:ALFA
Flufenamic acid Usage And Synthesis
Chemical Properties
Pale-Yellow Solid
Originator
Flufenamic acid,AroKor Holdings Inc.
Uses
Flufenamic acid is used for moderate pain and dysmenorrhea, but it should not be used for more than 1 week due to the possibility of nephrotoxicity, gastrointestinal toxicity, and anemia. It is frequently used in combination with the anticoagulant warfarin, the effect of which is strengthened when combined with flufenamic acid.
Uses
Anti-inflammatory; analgesic
Manufacturing Process
A mixture 31.3 g of o-chlorobenzoic acid, 32.2 g of trifluoromethyl-maminobenzene, 3 g of copper powder, 13.8 g of waterless potassium carbonate and 100 ml amyl alcohol was refluxed for 4 hours. To the cooled mixture was added 25 ml of 10 N solution NaOH and the mixture was concentrated and filtrated. Addition to the filtrate hydrochloric acid and water give a sediment of 2-((3-trifluromethyl)phenyl)aminobenzoic acid. After recrystallization from hexane 2-((3-trifluromethyl)phenyl)aminobenzoic acid have melting point 134-136°C.
brand name
Arlef (Parke-Davis).
Therapeutic Function
Antiinflammatory, Antirheumatic
Chemical Synthesis
Flufenamic acid, N-(α,α,α-trifluoro-m-tolyl)anthranylic acid (3.2.18), is synthesized by the reaction of 2-chlorobenzoic acid with 3-trifluoromethylaniline in the presence of potassium carbonate and copper filings [78,79].
Flufenamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Flufenamic acid(530-78-9)Related Product Information
- Prefenamate
- N-(3,5-BIS-TRIFLUOROMETHYLPHENYL)ANTHRANILIC ACID
- ufenamate
- METHYL 2-(3-TRIFLUOROMETHYLPHENYLAMINO)-BENZOATE
- Etofenamate
- Flufenamic acid
- 4-Dimethylaminobenzoic acid
- α-Lipoic Acid
- TOLUALDEHYDES
- Folic acid
- 4-(Trifluoromethyl)benzoic acid
- Ascoric Acid
- 4-Aminobenzoic acid
- Niflumic acid
- 3-(Trifluoromethyl)benzoic acid
- Citric acid
- Anthranilic acid
- Ethyl 2-(Chlorosulfonyl)acetate
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