Flufenamic acid Chemical Properties

Melting point:

132-135 °C(lit.)

Boiling point:

373.9±42.0 °C(Predicted)

Density 

1.3380 (estimate)

storage temp. 

Refrigerator

form 

Crystalline Powder or Chunks

pka

pKa 3.9 (Uncertain);3.85 (Uncertain)

color 

Off-white to gray-green

Water Solubility 

0.0265 g/L (37 ºC)

Merck 

14,4132

BRN 

1996069

CAS DataBase Reference

530-78-9(CAS DataBase Reference)

NIST Chemistry Reference

Flufenamic acid(530-78-9)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/38

Safety Statements 

26

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

CB4375000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29224999

Toxicity

LD50 in mice: 715 mg/kg orally (Zoni)

MSDS

• Language:EnglishProvider:Flufenamic acid
• Language:EnglishProvider:SigmaAldrich
• Language:EnglishProvider:ACROS
• Language:EnglishProvider:ALFA

Flufenamic acid Usage And Synthesis

Chemical Properties

Pale-Yellow Solid

Originator

Flufenamic acid,AroKor Holdings Inc.

Uses

Flufenamic acid is used for moderate pain and dysmenorrhea, but it should not be used for more than 1 week due to the possibility of nephrotoxicity, gastrointestinal toxicity, and anemia. It is frequently used in combination with the anticoagulant warfarin, the effect of which is strengthened when combined with flufenamic acid.

Uses

Anti-inflammatory; analgesic

Manufacturing Process

A mixture 31.3 g of o-chlorobenzoic acid, 32.2 g of trifluoromethyl-maminobenzene, 3 g of copper powder, 13.8 g of waterless potassium carbonate and 100 ml amyl alcohol was refluxed for 4 hours. To the cooled mixture was added 25 ml of 10 N solution NaOH and the mixture was concentrated and filtrated. Addition to the filtrate hydrochloric acid and water give a sediment of 2-((3-trifluromethyl)phenyl)aminobenzoic acid. After recrystallization from hexane 2-((3-trifluromethyl)phenyl)aminobenzoic acid have melting point 134-136°C.

brand name

Arlef (Parke-Davis).

Therapeutic Function

Antiinflammatory, Antirheumatic

Chemical Synthesis

Flufenamic acid, N-(α,α,α-trifluoro-m-tolyl)anthranylic acid (3.2.18), is synthesized by the reaction of 2-chlorobenzoic acid with 3-trifluoromethylaniline in the presence of potassium carbonate and copper filings [78,79].

Flufenamic acid(530-78-9)Related Product Information

• Prefenamate
• N-(3,5-BIS-TRIFLUOROMETHYLPHENYL)ANTHRANILIC ACID
• ufenamate
• METHYL 2-(3-TRIFLUOROMETHYLPHENYLAMINO)-BENZOATE
• Etofenamate
• Flufenamic acid
• 4-Dimethylaminobenzoic acid
• α-Lipoic Acid
• TOLUALDEHYDES
• Folic acid
• 4-(Trifluoromethyl)benzoic acid
• Ascoric Acid
• 4-Aminobenzoic acid
• Niflumic acid
• 3-(Trifluoromethyl)benzoic acid
• Citric acid
• Anthranilic acid
• Ethyl 2-(Chlorosulfonyl)acetate