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Flufenamic acid

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Flufenamic acid Basic information

Product Name:
Flufenamic acid
CAS:
530-78-9
MF:
C14H10F3NO2
MW:
281.23
EINECS:
208-494-1
Mol File:
530-78-9.mol
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Flufenamic acid Chemical Properties

Melting point:
132-135 °C(lit.)
Boiling point:
373.9±42.0 °C(Predicted)
Density 
1.3380 (estimate)
storage temp. 
Refrigerator
form 
Crystalline Powder or Chunks
pka
pKa 3.9 (Uncertain);3.85 (Uncertain)
color 
Off-white to gray-green
Water Solubility 
0.0265 g/L (37 ºC)
Merck 
14,4132
BRN 
1996069
CAS DataBase Reference
530-78-9(CAS DataBase Reference)
NIST Chemistry Reference
Flufenamic acid(530-78-9)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/38
Safety Statements 
26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
CB4375000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29224999
Toxicity
LD50 in mice: 715 mg/kg orally (Zoni)

MSDS

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Flufenamic acid Usage And Synthesis

Chemical Properties

Pale-Yellow Solid

Originator

Flufenamic acid,AroKor Holdings Inc.

Uses

Flufenamic acid is used for moderate pain and dysmenorrhea, but it should not be used for more than 1 week due to the possibility of nephrotoxicity, gastrointestinal toxicity, and anemia. It is frequently used in combination with the anticoagulant warfarin, the effect of which is strengthened when combined with flufenamic acid.

Uses

Anti-inflammatory; analgesic

Manufacturing Process

A mixture 31.3 g of o-chlorobenzoic acid, 32.2 g of trifluoromethyl-maminobenzene, 3 g of copper powder, 13.8 g of waterless potassium carbonate and 100 ml amyl alcohol was refluxed for 4 hours. To the cooled mixture was added 25 ml of 10 N solution NaOH and the mixture was concentrated and filtrated. Addition to the filtrate hydrochloric acid and water give a sediment of 2-((3-trifluromethyl)phenyl)aminobenzoic acid. After recrystallization from hexane 2-((3-trifluromethyl)phenyl)aminobenzoic acid have melting point 134-136°C.

brand name

Arlef (Parke-Davis).

Therapeutic Function

Antiinflammatory, Antirheumatic

Chemical Synthesis

Flufenamic acid, N-(α,α,α-trifluoro-m-tolyl)anthranylic acid (3.2.18), is synthesized by the reaction of 2-chlorobenzoic acid with 3-trifluoromethylaniline in the presence of potassium carbonate and copper filings [78,79].

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Flufenamic acidSupplierMore

Zhejiang Qiming Pharmaceutical Co., Ltd. Gold
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+86-571-87163895 +86-571-87163893
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sales@qimingpharm.com
J & K SCIENTIFIC LTD.
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400-666-7788 010-82848833-
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jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
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400-660-8290 21-61259100-
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sh@meryer.com
Alfa Aesar
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400-610-6006
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TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
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