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Calcium citrate

Basic information Description References Safety Related Supplier

Calcium citrate Basic information

Product Name:
Calcium citrate
CAS:
813-94-5
MF:
C12H10Ca3O14
MW:
498.43
EINECS:
212-391-7
Mol File:
813-94-5.mol
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Calcium citrate Chemical Properties

solubility 
0.1 M HCl: 0.01 M at 20 °C, clear, colorless
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
813-94-5(CAS DataBase Reference)
EPA Substance Registry System
Tricalcium citrate (813-94-5)
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Safety Information

WGK Germany 
1
Hazardous Substances Data
813-94-5(Hazardous Substances Data)
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Calcium citrate Usage And Synthesis

Description

Calcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid. Calcium citrate is present in foods which have naturally occurring citric acid. Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Calcium citrate may be chemopreventive for colon and other cancers. Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt. It is also used to improve the baking properties of flours and as a stabilizer.

References

  1. https://www.cancer.gov
  2. https://www.drugs.com
  3. https://www.webmd.com
  4. https://www.livestrong.com
  5. https://www.ams.usda.gov

Description

Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 21% of calcium citrate by weight.

Chemical Properties

white powder or white to colourless crystals

Production Methods

Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.

Pharmaceutical Applications

Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this.

Biological Activity

In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.

Calcium citrate Preparation Products And Raw materials

Raw materials

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Calcium citrateSupplierMore

Lianyungang Kexin Chemical Co., Ltd. Gold
Tel:
18805133257
Email:
sales3257@jskolod.com
Adamas Reagent, Ltd.
Tel:
400-600-9262
Email:
bxy@titansci.com
Sinopharm Chemical Reagent Co,Ltd.
Tel:
86-21-63210123
Email:
sj_scrc@sinopharm.com
Wuhan Fortuna Chemical Co., Ltd
Tel:
027-59207852-
Email:
sales@fortunachem.com
Beijing Universal Century Technology Co., Ltd.
Tel:
400-8706899
Email:
hysj_bj.com
Basic information Description References Safety Related Supplier