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Ethyl isocyanoacetate

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Ethyl isocyanoacetate Basic information

Product Name:
Ethyl isocyanoacetate
CAS:
2999-46-4
MF:
C5H7NO2
MW:
113.11
EINECS:
221-077-9
Mol File:
2999-46-4.mol
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Ethyl isocyanoacetate Chemical Properties

Boiling point:
194-196 °C(lit.)
Density 
1.035 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.418(lit.)
Flash point:
184 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear amber to dark brown
Water Solubility 
Miscible with organic solvents. Slightly miscible with water.
Sensitive 
Moisture & Light Sensitive
BRN 
3588613
CAS DataBase Reference
2999-46-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/22-20/21/22
Safety Statements 
36/37/39-26-36/37-24/25
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
8-9-21
HazardClass 
6.1
PackingGroup 
III
HS Code 
29299090

MSDS

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Ethyl isocyanoacetate Usage And Synthesis

Chemical Properties

Light yellow to brom liquid

Uses

Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.

Preparation

synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).

Ethyl isocyanoacetate Preparation Products And Raw materials

Preparation Products

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Ethyl isocyanoacetateSupplierMore

Zhangjiagang huamao Fine chemical Co.,Ltd. Gold
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18261880368
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ydzhou0515@126.com
Shanghai yongzeng technology co., LTD Gold
Tel:
15921781258 021-65925639-
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sales@yongzchem.com
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd. Gold
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15862625988 0512-58813106-
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clentchem@126.com
Sichuan Yunyidian Pharmaceutical Technology Co., Ltd. Gold
Tel:
18728483291
Email:
info@cdyunyidian.com;sales@cdyunyidian.com
Creasyn Finechem(Tianjin) Co., Ltd.
Tel:
022-83945878-
Email:
export@creasyn.com
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