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Diltiazem hydrochloride Structure

Diltiazem hydrochloride

Chemical Properties

Melting point 212-214 °C
alpha  D24 +98.3 ± 1.4° (c = 1.002 in methanol)
Density  1.30 g/cm3
refractive index  118 ° (C=1, H2O)
Flash point 2℃
storage temp.  2-8°C
solubility  Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.
form  Powder
color  White to off-white
PH pH (10g/l, 25℃) : 4.3~5.3
Water Solubility  soluble
Merck  13,3226
BRN  4228706
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference 33286-22-5(CAS DataBase Reference)
EPA Substance Registry System 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)- (33286-22-5)

Safety Information

Hazard Codes  Xn,Xi,F
Risk Statements  22-40-36/37/38-36-20/21/22-11
Safety Statements  36-45-36/37-26-16
RIDADR  3249
WGK Germany  3
RTECS  DL0310000
8-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)

Usage And Synthesis

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