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Cycloleucine

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Cycloleucine Basic information

Product Name:
Cycloleucine
CAS:
52-52-8
MF:
C6H11NO2
MW:
129.16
EINECS:
200-144-6
Mol File:
52-52-8.mol
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Cycloleucine Chemical Properties

Melting point:
320 °C (dec.)(lit.)
Boiling point:
239.22°C (rough estimate)
Density 
1.1426 (rough estimate)
refractive index 
1.4827 (estimate)
storage temp. 
Store at RT.
pka
2.38±0.20(Predicted)
form 
Crystalline Flakes or Powder
color 
White to beige
Water Solubility 
5 g/100 mL
Merck 
14,2734
BRN 
636626
CAS DataBase Reference
52-52-8(CAS DataBase Reference)
NIST Chemistry Reference
Cyclopentanecarboxylic acid, 1-amino-(52-52-8)
EPA Substance Registry System
Cyclopentanecarboxylic acid, 1-amino- (52-52-8)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22
Safety Statements 
22-24/25
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
GY2625000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29224999
Hazardous Substances Data
52-52-8(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 290mg/kg

MSDS

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Cycloleucine Usage And Synthesis

Chemical Properties

WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER

Uses

NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist

Uses

Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies

Definition

ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.

Purification Methods

Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]

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CycloleucineSupplierMore

Amatek Scientific Co. Ltd. Gold
Tel:
0512-56316828;0512-56316822
Email:
sales@amateksci.com;sales@amateksci.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
INTATRADE GmbH
Tel:
+49 3493/605464
Email:
sales@intatrade.de
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
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