Pirimiphos-methyl Chemical Properties
- Melting point:
- Boiling point:
- 386.5±52.0 °C(Predicted)
- d30 1.157
- vapor pressure
- 1.5×10-2 Pa (30°C)
- refractive index
- nD25 1.527
- Flash point:
- -18 °C
- storage temp.
- APPROX 4°C
- Water Solubility
- 9.9 mg l-1 (30 °C, pH 5.2)
- CAS DataBase Reference
- 29232-93-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Pirimiphos methyl(29232-93-7)
- EPA Substance Registry System
- Pirimiphos-methyl (29232-93-7)
Pirimiphos-methyl Usage And Synthesis
Light yellow, straw colored, or amber oily liquid. Odorless when pure.
Pirimiphos-methyl is used to control a wide range of insect and mite pests in stored products and a wide range of insects and mites on agricultural crops, particularly sucking pests under glass.
Pirimiphos-methyl is a phosphorothioate used as an insecticide. Pirimiphos-methyl is commonly used for mosquito control as well as control of greenhouse crop pests and stored-product insects.
ChEBI: An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2.
Yellow liquid. Corrosive to tin and mild steel. Used as an insecticide.
Air & Water Reactions
Hydrolyzed by strong acid or base.
Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Insecticide, Acaricide: Pirimiphos-methyl is a post-harvest insecticide used to control a variety of insects in stored grain products and seed such as corn, rice, wheat and sorghum. It is also incorporated into cattle ear tags, and used for the fogging treatment of iris bulbs and pre-harvest clean up of fruits and vegetables.
ACTELLIC®; ACTELLIFOG®; BLEX®; ENT 27699Gc®; DOMINATOR® EAR TAG; DOUBLE BARREL® EAR TAG; PLANT PROTECTION PP511®; PP511®; SILOSAN®; SYBOL®; TOMAHAWK®[C]
Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.
Pirimiphos-methyl is a post -harves organophosphate insecticide/acaricide used to control a variety of insects in stored grain products and seed such as corn, rice, wheat and sorghum. It is also incorporated into cattle ear tags, and used for the fogging treatment of iris bulbs and preharvest cleanup of fruits and vegetables.
When rats were given diets with 0, 10, 50, or 300 ppm pirimiphos methyl (equivalent to 0, 0.4, 2.1, or 12.6 mg/kg/day) for 2 years, 4 of the 42 high-dose male rats had pancreatic islet cell adenomas and 1 had a carcinoma compared to none in control male rats . In a carcinogenicity study, mice were given diets with 0, 50, 200, or 400/300 ppm pirimiphos methyl (equivalent to 0, 8.3, 33, or 52 mg/kg/day (males); 0, 9.7, 39, or 61 mg/kg/day (females)) for 78 weeks . The initial 400 ppm dose resulted in excessive toxicity and moribundity and was reduced to 300 ppm after 8 days. There was no evidence of carcinogenicity. In another mouse carcinogenicity study, pirimiphos methyl was administered in the diet at levels of 0, 5, 250, or 500 ppm (equivalent to 0, 0.5, 25.9, or 45.0 mg/kg/ day (males) and 0, 0.6, 27.6, or 50.6 mg/kg/day (females), respectively) for 80 weeks. The test diet for the highest dose groups initially contained 300 ppm of the test compound (the duration of treatment was not specified). The dose was then increased weekly by 50 ppm to 500 ppm. No evidence of carcinogenicity was observed.
The metabolism of pirimiphos-methyl is similar in soils, plants and animals and can be represented by initial hydrolysis to yield 2-diethylamino- 6-methyl-p yrimidin-4-0l which may be either conjugated or successively N-de-ethylated. In plants, pirimiphos-methyl itself is N-de-ethylated. It is probable that the oxon form of the compound is formed in many systems but it is more labile than the parent compound and is often not detected. 0-Dealkylation, as with most organophosphates, is most probably a major detoxification route in mammals but the evidence for it in the case of pirimiphos-methyl is poor.
UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Pirimiphos-methyl is hydrolysed under both acidic and basic conditions and is most stable at pH 7 (PM). The main product of hydrolysis was the pyrimidinol (2). There is no information, however, on the degradation products formed under either acidic or basic conditions. The DT50 of degradation was in the range of 3-4 days in sterile deionised water in the dark. Photolysis was rapid but the products of photolytic breakdown were not described (PSD, 1997).
May react violently with antimony(V) pentafluoride. Incompatible with strong acids and alkalies, lead diacetate, magnesium, silver nitrate. In the presence of strong reducing agents such as hydrides, organophosphates form highly toxic and flammable phosphine gas. Contact with oxidizers can cause the release of toxic oxides of phosphorus.
Destruction by alkali hydrolysis or incineration. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
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