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Diphenhydramine Hydrochloride

Basic information Description Clinical Pharmacology Indications and Usage Drug overdose Contraindications Safety Related Supplier

Diphenhydramine Hydrochloride Basic information

Product Name:
Diphenhydramine Hydrochloride
CAS:
147-24-0
MF:
C17H22ClNO
MW:
291.82
EINECS:
205-687-2
Mol File:
147-24-0.mol
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Diphenhydramine Hydrochloride Chemical Properties

Melting point:
168-172 °C
Boiling point:
163-167 °C(Press: 3 Torr)
Density 
1.0489 (rough estimate)
refractive index 
1.5800 (estimate)
Flash point:
9℃
storage temp. 
Desiccate at RT
solubility 
Very soluble in water, freely soluble in alcohol.
form 
Crystalline Powder or Adhering Crystals
color 
White
PH
pH(100g/L, 25℃) 4.0~5.5
Water Solubility 
1000 g/L
Sensitive 
Light Sensitive
Merck 
14,3309
Stability:
Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
InChIKey
PCHPORCSPXIHLZ-UHFFFAOYSA-N
CAS DataBase Reference
147-24-0(CAS DataBase Reference)
NIST Chemistry Reference
diphenhydramine hydrochloride(147-24-0)
EPA Substance Registry System
Diphenhydramine hydrochloride (147-24-0)
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
36-45-36/37-16-7-24/25
RIDADR 
2811
WGK Germany 
3
RTECS 
KR7000000
HS Code 
29221990
Toxicity
LD50 orally in rats: 500 mg/kg (Gruhzit, Fisken)

MSDS

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Diphenhydramine Hydrochloride Usage And Synthesis

Description

Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Diphenhydramine hydrochloride structural formula
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.

Clinical Pharmacology

Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available.

Indications and Usage

Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.

  1. antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
  2. Motion Sickness: For active treatment of motion sickness.
  3. Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.

Drug overdose

Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be used to treat hypotension.

Contraindications

  1. Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.
  2. Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
  3. Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
  4. Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.

Chemical Properties

White or almost white, crystalline powder.

Uses

Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.

Uses

antihistamine, sedative, treatment of allergic

Uses

A histamine H1-receptor antagonist.

Uses

H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic

Definition

ChEBI: The hydrochloride salt of diphenhydramine.

brand name

Benadryl (Parke-Davis).

General Description

Diphenhydramine hydrochloride, 2-(diphenylmethoxy)- N,N-dimethylethanamine hydrochloride (Benadryl), is an oily, lipid-soluble free base available as the bitter-tasting hydrochloride salt, which is a stable, white crystalline powder soluble in water (1:1), alcohol (1:2) and chloroform (1:2). The salt has a pKa value of 9, and a 1% aqueous solution has a pH of about 5.
In addition to antihistaminic action, diphenhydramine exhibits antidyskinetic, antiemetic, antitussive and antimuscarinic, and sedative properties.As an antihistaminic agent, diphenhydramine is recommended in various allergic conditions and, to a lesser as an antitussive and Parkinsonism drug. It is also used in OTC sleep-aid products. It is administered either orally or parenterally in the treatment of urticaria, seasonal rhinitis (hay fever), and some dermatoses.

General Description

White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.

Air & Water Reactions

Water soluble. Aqueous solutions are acidic.

Reactivity Profile

N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.

Fire Hazard

Flash point data for N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride are not available; however, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride is probably combustible.

Biological Activity

H 1 receptor antagonist. Antihistamine.

Contact allergens

This antihistaminic drug with sedative properties is mainly sold over the counter. It can be used both topically (treatment of pruritis) and orally for its antiallergic, antiemetic, sedative, and anticough properties. Allergic or photoallergic contact dermatitis and fixeddrug eruption seem to be rare.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion or skin contact: arrhythmias, ataxia, blood pressure elevation, convulsions, distorted perceptions, eye effects, and hallucinations. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and HCl. See also ESTERS and ETHERS.

Veterinary Drugs and Treatments

In veterinary medicine, diphenhydramine is used principally for its antihistaminic effects, but also for other pharmacologic actions. Its sedative effects can be of benefit in treating the agitation (pruritus, etc.) associated with allergic responses. It has also been used for treatment and prevention of motion sickness and as an antiemetic in small animals. It has been suggested for use as adjunctive treatment of aseptic laminitis in cattle and it may be useful as an adjunctive treatment for feline pancreatitis. For other suggested uses, refer to the Dosage section below.

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Diphenhydramine HydrochlorideSupplierMore

Jinan Rouse Industry Co., Ltd. Gold
Tel:
0531-82929600-
Email:
sale@rousechem.com
Qufu Haida Tiancheng Biochemical Co., Ltd. Gold
Tel:
0537-4531868-
Email:
qfhdtc@126.com
Wuhan HongxinKang Fine Chemical Co., Ltd. Gold
Tel:
027-59362599 18674037007
Email:
zhuoxingwc@163.com
Hubei Bangsun Chemical Co., Ltd. Gold
Tel:
18171081685
Email:
2834045742@qq.com
Xiangtan Jiayeyuan Biotechnology Co., Ltd. Gold
Tel:
19972424735
Email:
fiona1@yccreate.com
Basic information Description Clinical Pharmacology Indications and Usage Drug overdose Contraindications Safety Related Supplier