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Idebenone

Basic information Description References Safety Related Supplier

Idebenone Basic information

Product Name:
Idebenone
CAS:
58186-27-9
MF:
C19H30O5
MW:
338.44
EINECS:
1308068-626-2
Mol File:
58186-27-9.mol
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Idebenone Chemical Properties

Melting point:
52-550C
Boiling point:
497.3±45.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
storage temp. 
Room temp
pka
15.20±0.10(Predicted)
form 
neat
Merck 
14,4888
InChIKey
JGPMMRGNQUBGND-UHFFFAOYSA-N
CAS DataBase Reference
58186-27-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
WGK Germany 
3
RTECS 
GU5290000
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Idebenone Usage And Synthesis

Description

Idebenone is an organic compound belonging to the quinone family, being similar to coenzyme Q-10. It is a kind of drug developed by Takeda Pharmaceutical Company for the treatment of Alzheimer’s disease and some other cognitive defects. However, these have been not very much progress associated with this indication. It is now also used for the treatment of Friedreich’s ataxia with a positive effect on cardiac hypertrophy and neurological function. However, this indication is only approved in Canada, not in Europe and US. It is now under investigation on its efficacy for the treatment of Duchenne muscular dystrophy, Leber’s hereditary optic neuropathy, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) as well as primary progressive multiple sclerosis. The efficacy of this drug still demands more evidences.

References

https://en.wikipedia.org/wiki/Idebenone
http://www.webmd.com/vitamins-supplements/ingredientmono-1078-idebenone.aspx?activeingredientid=1078&activeingredientname=idebenone

Description

Idebenone is a structural relative of ubiquinone (Coenzyme Q10) that protects the CNS from the effects of ischemia via improving brain metabolism. It is reported to be of potential use in the management of patients with cerebral apoplexy, cerebral arteriosclerosis and related disorders.

Chemical Properties

Yellow-Orange Crystalline Solid

Originator

Takeda (Japan)

Uses

cognition enhancer, nootropic

Uses

chemotherapy drug

Uses

Ubiquinone derivative with protective effects against cerebral ischemia. Nootropic

Uses

idebenone is an anti-oxidant capable of protecting the skin from a variety of free-radical attacks, including the formation of secondary chemicals that negatively affect skin physiology. It is said to improve intrinsic as well as extrinsic skin damage caused by freeradical formation. Idebenone is a synthetically manufactured form of coenzyme Q10 and has a smaller molecular structure. This allows it to penetrate the skin and apparently the cellular membrane. Clinical studies demonstrate a visible improvement in photodamaged skin, reduced skin roughness and dryness, decreased fine lines and wrinkles, and increased skin hydration. In addition, idebenone helps improve hyperpigmentation because its molecular structure is similar to that of hydroquinone. Although most of the associated benefits are seen primarily in the epidermis, some increase in dermal collagen has also been confirmed. Idebenone has been used for such health-related problems as Alzheimer’s and heart disease.

Definition

ChEBI: A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits ere modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.

brand name

AVAN

Biological Activity

Antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo . Inhibits apoptosis of astrocytes via increased NGF production.

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IdebenoneSupplierMore

Shaanxi billion Kang Long biological technology co., LTD Gold
Tel:
17791478691
Email:
997832940@qq.com
Guangzhou Tonghui Pharmaceutical Co., Ltd. Gold
Tel:
020-66392416
Email:
3004254637@qq.com
Puripharm Co., Ltd. Gold
Tel:
0572-2745768-1;0572-2717806-
Email:
sales@puripharm.com;yzm@puripharm.com
Xi'an Kono chem co., Ltd., Gold
Tel:
029-86107037-8012
Email:
sales9@konochemical.com
Shanghai Boyle Chemical Co., Ltd.
Tel:
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Email:
sales@boylechem.com
Basic information Description References Safety Related Supplier