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Tween 80

Basic information Description References Safety Related Supplier

Tween 80 Basic information

Product Name:
Tween 80
CAS:
9005-65-6
MF:
C24H44O6
MW:
428.600006103516
EINECS:
500-019-9
Mol File:
Mol File
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Tween 80 Chemical Properties

Boiling point:
>100°C
Density 
1.08 g/mL at 20 °C
vapor pressure 
<1 mm Hg ( 20 °C)
refractive index 
n20/D 1.473
FEMA 
2917 | POLYSORBATE 80
Flash point:
>230 °F
storage temp. 
Store at RT.
form 
viscous liquid
color 
Amber
Specific Gravity
1.080 (25/4℃)
PH
5-7 (50g/l, H2O, 20℃)
PH Range
6
Water Solubility 
5-10 g/100 mL at 23 ºC
Merck 
14,7582
Hydrophilic-Lipophilic Balance (HLB)
10
EPA Substance Registry System
Polysorbate 80 (9005-65-6)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
22-36/37/38-37/38-41
Safety Statements 
24/25-36/37/39-36-26
WGK Germany 
1
RTECS 
WG2934000
3
TSCA 
Yes
HS Code 
34021300
Hazardous Substances Data
9005-65-6(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (ml/kg): 7.5, 6.3 i.p. (Varma)

MSDS

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Tween 80 Usage And Synthesis

Description

Tween 80, commonly known as polysorbate 80, is a synthetic compound that is widely applied in a variety of fields, including foods, medicines, and cosmetics. In food production, it is commonly used as a defoamer for the fermenting process of some wines and as a emulsifier in ice-cream or “puddings” to keep the creamy texture without separating. Tween 80 is also extensively applied in pharmaceutical industry, where it can be found in some vaccines, vitamins and supplements. It is an effective excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, thus to make pills disperse in the stomach. Besides, it commonly serve as a surfactant and solubilizer in the production of soaps and cosmetics, which is effective to help dissolve ingredients and make products look creamier and more attractive. In laboratory, it is occasionally  used for a test to identify the phenotype of a strain or isolate, such as mycobacteria.

References

https://en.wikipedia.org/wiki/Polysorbate_80
http://thegoodhuman.com/what-is-polysorbate-80/
http://www.crodahealthcare.com/home.aspx?s=149&r=344&p=2259
https://pubchem.ncbi.nlm.nih.gov/compound/443315#section=Top

Chemical Properties

Polysorbate 80 has a faint, characteristic odor and a warm, somewhat bitter taste. It is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.

Chemical Properties

Yellow to amber liquid

Uses

Lonzest(R) SMO-20 is used as an emulsifier for textiles, personal care and industrial applications.

Uses

Lonzest(R) SMO-5 is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).

Uses

Glycolube(R) AFA-1 is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS.

Uses

Vinylube(R) 38 is an external lubricant for PVC bottle, film, and sheet components with excellent processing abilities and final clarity. It is also used as an antistatic agent. Product Data Sheet

Uses

Glycosperse(R) O-20 KFG is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations. Product Data Sheet

Uses

A non ionic detergent for cell lysis

Uses

As emulsifiers and dispersing agents in medicinal products; as defoamers and emulsifiers in foods. Pharmaceutic aid (surfactant).

Definition

ChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.

brand name

Sorlate (Abbott); Tween 80 (ICI Americas).

General Description

Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Tween 80 is incompatible with strong alkalis and oxidizers.

Fire Hazard

Tween 80 is probably combustible.

Safety Profile

Moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Tween 80 Preparation Products And Raw materials

Raw materials

Preparation Products

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Tween 80SupplierMore

Nantong jinlai chemical co. LTD Gold
Tel:
13806276680
Email:
13813751300@163.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
Tel:
021-20337333-801
Email:
market@aladdin-e.com
Spectrum Chemical Manufacturing Corp. Gold
Tel:
021-67601398-809
Email:
marketing_china@spectrumchemical.com;
Valiant Co., Ltd. Gold
Tel:
0535-6101831
Email:
liutao@valiant-cn.com
GUANGDONG RUNHUA CHEMISTRY CO.,LTD. Gold
Tel:
020-36293412-
Email:
bonnie@gdrunhua.com
Basic information Description References Safety Related Supplier