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phanquone

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phanquone Basic information

Product Name:
phanquone
CAS:
84-12-8
MF:
C12H6N2O2
MW:
210.19
EINECS:
201-516-0
Mol File:
84-12-8.mol
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phanquone Chemical Properties

Melting point:
295° (dec)
Boiling point:
349.71°C (rough estimate)
Density 
1.2785 (rough estimate)
refractive index 
1.6000 (estimate)
pka
-0.30±0.20(Predicted)
color 
Crystals from methanol
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Safety Information

Toxicity
LD50 orl-rat: 5 mg/kg ANTCAO 8,297,58 orl-mus LD50:4 mg/kg ANTCAO 8,297,58
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phanquone Usage And Synthesis

Originator

Phanquinone ,Yick-Vic Chemicals and

Definition

ChEBI: An orthoquinone that is the 5,6-diketo derivative of 4,7-phenanthroline.

Manufacturing Process

2 parts of 6-methoxy-4:7-phenanthroline are mixed with 10 parts by volume of concentrated sulfuric acid and while cooling with a mixture of ice and sodium chloride, with 6 parts by volume of fuming nitric acid (density = 1.51), and the whole is heated for 2 h at 120°C. The reaction solution is poured on to ice, its pH value is adjusted to 7 by means of a 10 N solution of caustic soda, after standing for 2 h the whole is filtered with suction to remove the precipitate which separates, and the latter is washed with hot water. After recrystallising the product from methyl alcohol and drying it at 100°C under 0.1 mm pressure, there are obtained 1.8 parts (i.e. 90 % of the calculated yield) of 4:7-phenanthroline-5:6-quinone in the form of pale yellow crystals melting at 295°C.

Therapeutic Function

Antiamebic

Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The dione crystallises from MeOH. The mono-oxime forms yellow crystals from MeOH with m 250o(dec), the di-oxime forms yellow crystals from MeOH with m 300o(dec) and the mono-semihydrazone forms yellow crystals from MeOH with m 195o(dec). [Druey & Schmidt Helv Chim Acta 33 1080 1950, Beilstein 24 III/IV 1741.]

phanquone Preparation Products And Raw materials

Raw materials

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phanquoneSupplierMore

Shanghai Puluokai Medical Technology Co., LTD Gold
Tel:
17269768198
Email:
prochemx@163.com
Shanghai Shenmin Industrial Co., Ltd.
Tel:
13601649268
Email:
hengyaosw@163.com
Suzhou Future Chemical Technology Co., Ltd.
Tel:
13921981169
Email:
ftchem2016@163.com
Zhengzhou Huiju Chemical Co., Ltd.
Tel:
18137872243 0371-55900031-
Email:
sales8@alfachem.cn;sales8@alfachem.cn
Shanghai Bank Pharma Limited
Tel:
021-54220652
Email:
bankpharma@163.com
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