Sodium thiosulfate pentahydrate
Sodium thiosulfate pentahydrate Chemical Properties
- Melting point:
- 48.5 °C
- Boiling point:
- 100 C
- 1.01 g/mL at 25 °C
- storage temp.
- Store at RT.
- H2O: 1 M at 20 °C, clear, colorless
- Specific Gravity
- White tranparent
- 6.0-7.5 (100g/l, H2O, 20℃)
- Water Solubility
- 680 g/L (20 ºC)
- Stable. Incompatible with strong acids, iodine, mercury.
- CAS DataBase Reference
- 10102-17-7(CAS DataBase Reference)
- EPA Substance Registry System
- Thiosulfuric acid (H2S2O3), disodium salt, pentahydrate (10102-17-7)
Sodium thiosulfate pentahydrate Usage And Synthesis
translucent crystals or white powder
Sodium thiosulfate occurs as odorless and colorless crystals, a crystalline powder or granules. It is efflorescent in dry air and deliquescent in moist air.
On an industrial scale, sodium thiosulfate is produced chiefly from liquid waste products of sodium sulfide or sulfur dye manufacture. Small-scale synthesis is done by boiling an aqueous solution of sodium sulfite with sulfur.
Sulfactol (Sterling Winthrop).
Sodium thiosulfate is used as an antioxidant in pharmaceuticals (ophthalmic, intravenous, and oral preparations). It has also been used for its antifungal properties and as a reagent in analytical chemistry.
Sodium thiosulfate is used in ophthalmic, intravenous, and oral
pharmaceutical preparations. Apart from osmotic disturbances,
sodium thiosulfate is relatively nontoxic. It is moderately toxic by the subcutaneous route and mildly irritating to respiratory tract and
skin. Large oral doses have a cathartic action.
LD50 (IP, mouse) 5.6 g/kg
LD50 (IV, mouse) 2.4 g/kg
Sodium thiosulfate decomposes on heating. The bulk powder should be stored in a cool place, and the container should be kept tightly closed in a dry and well-ventilated place. It should not be stored near acids.
Crystallise it from EtOH/H2O solutions or from water (0.3mL/g) below 60o by cooling to 0o, and dry it at 35o over P2O5 under vacuum. [Foerster & Mommsen Chem Ber 57 258 1924.] This salt is used as a secondary standard in volumetric analysis [Kilpatrick J Am Chem Soc 45 2132 1923], and is used as “Hypo” in photography [Hargreaves & Dunningham J Soc Chem Ind 42 147T 1923.]
Sodium thiosulfate is incompatible with iodine, with acids, and with lead, mercury, and silver salts. It may reduce the activity of some preservatives, including bronopol, phenylmercuric salts, and thimerosal.
GRAS listed. Included in the FDA Inactive Ingredients Database (IV solutions; ophthalmic solutions and suspensions; oral capsules, solutions, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium thiosulfate pentahydrate Preparation Products And Raw materials
- GOLD SODIUM THIOSULFATE HYDRATE
- GOLD (I) SODIUM THIOSULFATE
- GOLD(I) SODIUM THIOSULFATE HYDRATE
- ETHYLENEDIAMINE TETRAKIS(PROPOXYLATE-BLOCK-ETHOXYLATE) TETROL
- Sodium thiosulfate pentahydrate
- Sodium acetate
- Sodium chloride
- Sodium bicarbonate
- Sodium sulfate
- 5-Chlorovaleric acid
- Diphenolic acid
- Sodium hydroxide
- Diclofenac sodium
- Sodium thiosulfate
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