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Rutin

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Rutin Basic information

Product Name:
Rutin
CAS:
153-18-4
MF:
C27H30O16
MW:
610.52
EINECS:
205-814-1
Mol File:
153-18-4.mol
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Rutin Chemical Properties

Melting point:
195 °C (dec.)(lit.)
alpha 
D23 +13.82° (ethanol); D23 -39.43° (pyridine)
Boiling point:
576.13°C (rough estimate)
Density 
1.3881 (rough estimate)
refractive index 
1.7650 (estimate)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
pyridine: 50 mg/mL
form 
powder
pka
6.17±0.40(Predicted)
Colour Index 
75730
color 
yellow to green
Water Solubility 
12.5 g/100 mL
Merck 
8304
CAS DataBase Reference
153-18-4(CAS DataBase Reference)
NIST Chemistry Reference
Flavone-3-rutinoside, 3,3',4',5,7-pentahydroxy(153-18-4)
EPA Substance Registry System
Rutin (153-18-4)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
VM2975000
8
HS Code 
29381000
Toxicity
LD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison)

MSDS

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Rutin Usage And Synthesis

Chemical Properties

Pale-Yellow Crystalline Solid

Uses

Found in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions.

Uses

antidiabetic, dipeptidyl peptidase–4 inhibitor

Uses

For nutritional product

Uses

rutin is described as helping to tighten and strengthen skin capillaries, and as such it could help prevent a couperose condition. It also demonstrates anti-oxidant properties. Rutin is a flavonoid found in rue leaves, buckwheat, and other plants.

Definition

ChEBI: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.

Purification Methods

The vitamin crystallises from MeOH or water/EtOH, dry it in air, then dry it further for several hours at 110o or in high vacuum at 120o. It forms yellow crystals from EtOH/Me2CO/H2O (2:1:1). It has also been purified by passing (0.5g) through a Kieselgel column (30 x 5cm) with EtOAc/MeOH/H2O (100:20:15), and after 750mL have passed through, the yellow fraction of 250mL gives the glycoside (0.3g) on evaporation. [H.rhammer et al. Chem Ber 101 1183 1968, Marini-Bettòlo Gazz Chim Ital 80 631 1950, Beilstein 18/5 V 519.]

Rutin Preparation Products And Raw materials

Preparation Products

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Shanghai Orgchem Co.,Ltd. Gold
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Sichuan Benepure Pharmaceutical Co., Ltd. Gold
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028-86799990-207;028-86799990-101
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