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Clindamycin phosphate

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Clindamycin phosphate Basic information

Product Name:
Clindamycin phosphate
CAS:
24729-96-2
MF:
C18H34ClN2O8PS
MW:
504.97
EINECS:
246-433-0
Mol File:
24729-96-2.mol
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Clindamycin phosphate Chemical Properties

Melting point:
114 °C
Boiling point:
159°C
Density 
1.41±0.1 g/cm3(Predicted)
refractive index 
122 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
DMSO: soluble224mg/mL at 25°C
form 
solid
pka
pKa 0.964±0.06 (H2O t=21) (Uncertain);6.06 ±0.06 (I=0.008)(H2O t=21) (Uncertain)
Water Solubility 
Freely soluble in water
Merck 
14,2356
Stability:
Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26
WGK Germany 
3
RTECS 
GF2625000
HS Code 
29419000

MSDS

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Clindamycin phosphate Usage And Synthesis

Chemical Properties

solid

Uses

Lincosamide antibacterial.

Uses

Clindamycin (C580000) impurity in bulk drug.

Uses

A highly water soluble Clindamycin prodrug.

Uses

Clindamycin 2-phosphate is a a salt of clincamycin, a semi-synthetic lincosamide. The salt is prepared by selective phosphorylation of the 2-hydroxy moiety of the sugar of clindamycin. The introduction of the phosphate affords improved solubility for injectable formulations. Like other members of the lincosamide family, clindamycin 2-phosphate is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis.

Uses

Clindamycin 2-phosphate is a salt of clindamycin, a semi-synthetic lincosamide. The salt is prepared by selective phosphorylation of the 2-hydroxy moiety of the sugar of clindamycin. The introduction of the phosphate affords improved solubility for injectable formulations. Like other members of the lincosamide family, clindamycin 2-phosphate is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis.

General Description

Clindamycin phosphate (Cleocin Phosphate) is the 2-phosphateester of clindamycin. It exists as a zwitterionic structurethat is very soluble in water. It is intended for parenteral(intravenous or intramuscular) administration for the treatmentof serious infections and instances when oral administrationis not feasible. Solutions of clindamycin phosphateare stable at room temperature for 16 days and for up to 32days when refrigerated.

Contact allergens

This lincosanide antibiotic is used in topical form for acne, or systemically has been responsible for exanthematous rashes and acute generalized exanthematous pustulosis.

Clindamycin phosphate Preparation Products And Raw materials

Raw materials

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WuHan YuanCheng Gongchuang Technology Co.Ltd Gold
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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sh@meryer.com
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