Ethacrynic acid Chemical Properties
- Melting point:
- 125 °C
- Boiling point:
- 480.0±45.0 °C(Predicted)
- 1.3562 (estimate)
- storage temp.
- -20?C Freezer
- DMSO: soluble20mg/mL, clear
- 3.50(at 25℃)
- white to beige
- Water Solubility
- Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.
- CAS DataBase Reference
- 58-54-8(CAS DataBase Reference)
- EPA Substance Registry System
- Ethacrynic acid (58-54-8)
- Language:EnglishProvider:2-[2,3-Dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
Ethacrynic acid Usage And Synthesis
A diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.
ChEBI: An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 220.127.116.11) inhibitor.
Air & Water Reactions
Insoluble in water.
Ethacrynic acid may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. May react exothermically with acids. Reacts exothermically with all bases both organic (for example, the amines) and inorganic.
Ethacrynic acid is probably combustible.
Veterinary Drugs and Treatments
Ethacrynic acid is a loop diuretic that shares the same indications
as furosemide (congestive cardiomyopathy, pulmonary edema, hypercalcuric
nephropathy, uremia, as adjunctive therapy in hyperkalemia
and, occasionally, as an antihypertensive agent). Its use has
been largely supplanted in the armamentarium by furosemide for
Ethacrynic acid may be useful in the treatment of nephrogenic diabetes insipidus as it may cause a paradoxical decrease in urine volume. Other uses include the adjunctive treatment of hypercalcemia and to increase the excretion of bromide in the treatment of bromide toxicity.
Ethacrynic acid Preparation Products And Raw materials
- (4-METHYLPHENOXY)ACETIC ACID
- 2-Chloro-4-hydroxybenzaldehyde 98%
- 2-Chlorophenoxyacetic acid
- 2,3-DICHLOROPHENOXYACETIC ACID
- Ethacrynic acid
- Dichloroacetic acid methyl ester
- Sodium dichloroacetate
- Ascoric Acid
- Ethyl 2-(Chlorosulfonyl)acetate
- Citric acid
- Folic acid
- Please Email