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Ethacrynic acid

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Ethacrynic acid Basic information

Product Name:
Ethacrynic acid
CAS:
58-54-8
MF:
C13H12Cl2O4
MW:
303.14
EINECS:
200-384-1
Mol File:
58-54-8.mol
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Ethacrynic acid Chemical Properties

Melting point:
125 °C
Boiling point:
480.0±45.0 °C(Predicted)
Density 
1.3562 (estimate)
storage temp. 
-20?C Freezer
solubility 
DMSO: soluble20mg/mL, clear
pka
3.50(at 25℃)
form 
powder
color 
white to beige
Water Solubility 
Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.
Merck 
3717
CAS DataBase Reference
58-54-8(CAS DataBase Reference)
EPA Substance Registry System
Ethacrynic acid (58-54-8)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AG6600000
HS Code 
2918992090
Hazardous Substances Data
58-54-8(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 176 i.v.; 627 orally (Peck)

MSDS

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Ethacrynic acid Usage And Synthesis

Chemical Properties

White Solid

Uses

A diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.

Definition

ChEBI: An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.

brand name

Edecrin (Merck).

General Description

White solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Ethacrynic acid may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. May react exothermically with acids. Reacts exothermically with all bases both organic (for example, the amines) and inorganic.

Fire Hazard

Ethacrynic acid is probably combustible.

Veterinary Drugs and Treatments

Ethacrynic acid is a loop diuretic that shares the same indications as furosemide (congestive cardiomyopathy, pulmonary edema, hypercalcuric nephropathy, uremia, as adjunctive therapy in hyperkalemia and, occasionally, as an antihypertensive agent). Its use has been largely supplanted in the armamentarium by furosemide for these indications.
Ethacrynic acid may be useful in the treatment of nephrogenic diabetes insipidus as it may cause a paradoxical decrease in urine volume. Other uses include the adjunctive treatment of hypercalcemia and to increase the excretion of bromide in the treatment of bromide toxicity.

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Ethacrynic acidSupplierMore

Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
Nanjing Chemlin Chemical Co., Ltd
Tel:
025-83697070
Email:
info@chemlin.com.cn
Chemsky(shanghai)International Co.,Ltd.
Tel:
021-50135380
Email:
shchemsky@sina.com
Syntechem Co.,Ltd
Tel:
Please Email
Email:
info@syntechem.com
Sinopharm Chemical Reagent Co,Ltd.
Tel:
86-21-63210123
Email:
sj_scrc@sinopharm.com
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