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Fenofibrate

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Fenofibrate Basic information

Product Name:
Fenofibrate
CAS:
49562-28-9
MF:
C20H21ClO4
MW:
360.83
EINECS:
256-376-3
Mol File:
49562-28-9.mol
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Fenofibrate Chemical Properties

Melting point:
80-810C
Boiling point:
469.8±35.0 °C(Predicted)
Density 
1.177±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Practically insoluble in water, very soluble in methylene chloride, slightly soluble in ethanol (96 per cent)
form 
powder
color 
off-white
Water Solubility 
0.8mg/L(25 ºC)
Merck 
14,3978
EPA Substance Registry System
Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethyl ester (49562-28-9)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26-24/25
WGK Germany 
3
RTECS 
UA2453400
HS Code 
29189900
Toxicity
LD50 in mice: 1600 mg/kg orally (Sornay)

MSDS

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Fenofibrate Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

antihyperlipidemic

Uses

Cardiovascular disease

Uses

Antilipemic. It is a lipid regulating drug. Increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expresion.

Definition

ChEBI: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.

General Description

Fenofibrate, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester (Tricor),has structural features represented in clofibrate. The primarydifference involves the second aromatic ring. This imparts agreater lipophilic character than exists in clofibrate, resultingin a much more potent hypocholesterolemic and triglycerideloweringagent. Also, this structural modification results in alower dose requirement than with clofibrate or gemfibrozil.

Fenofibrate Preparation Products And Raw materials

Raw materials

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FenofibrateSupplierMore

Wuhan Runzeweiye Technology Co., Ltd. Gold
Tel:
027-50779735-
Email:
runzeweiye999@163.com;
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
INTATRADE GmbH
Tel:
+49 3493/605464
Email:
sales@intatrade.de
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
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