Basic information Non-steroidal anti-inflammatory drugs Chemical Properties Uses Used in Particular Diseases production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent Safety Related Supplier
Naproxen Structure

Naproxen

Chemical Properties

Melting point 152-154 °C (lit.)
alpha  D +66° (in chloroform)
Boiling point 332.25°C (rough estimate)
Density  1.1450 (rough estimate)
refractive index  67.5 ° (C=1, CHCl3)
Flash point 9℃
storage temp.  2-8°C
solubility  Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
form  powder
pka pKa 4.28± 0.02(H2O,t =25,I=0.01) (Uncertain)
color  White to Almost white
optical activity [α]25/D +66°, c = 1 in chloroform
Water Solubility  Insoluble in water.
Merck  14,6417
BRN  3591067
BCS Class 2
LogP 3.18
CAS DataBase Reference 22204-53-1(CAS DataBase Reference)
NIST Chemistry Reference Naproxen(22204-53-1)
EPA Substance Registry System 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (.alpha.S)- (22204-53-1)

Safety Information

Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements  36/37-45-16-7-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  UF5275000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29189900
Hazardous Substances Data 22204-53-1(Hazardous Substances Data)
Toxicity LD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski)

MSDS

Usage And Synthesis

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