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Propylamine

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Propylamine Basic information

Product Name:
Propylamine
CAS:
107-10-8
MF:
C3H9N
MW:
59.11
EINECS:
203-462-3
Mol File:
107-10-8.mol
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Propylamine Chemical Properties

Melting point:
-83 °C
Boiling point:
48 °C(lit.)
Density 
0.719 g/mL at 25 °C(lit.)
vapor density 
2 (vs air)
vapor pressure 
4.79 psi ( 20 °C)
refractive index 
n20/D 1.388(lit.)
FEMA 
4237 | PROPYLAMINE
Flash point:
−35 °F
storage temp. 
0-6°C
solubility 
water: soluble0.4 part(lit.)
pka
10.6(at 20℃)
form 
Liquid
color 
Clear colorless to pale yellow
Specific Gravity
0.7173
PH
12.6 (100g/l, H2O, 20℃)
Odor Threshold
0.061ppm
explosive limit
2.1-13.6%(V)
Water Solubility 
soluble
Sensitive 
Air Sensitive
JECFA Number
1580
Merck 
14,7843
BRN 
1098243
Exposure limits
No exposure limit has been set. Based on its similarity to ethylamine in irritation and toxicity, a TLV-TWA of 10 ppm (~24 mg/m3) should be appropriate. .
Stability:
Stable. Highly flammable. Note low flash point. Readily forms explosive mixtures with air. Incompatible with oxidising agents, strong acids. Store cool.
CAS DataBase Reference
107-10-8(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanamine(107-10-8)
EPA Substance Registry System
Propylamine (107-10-8)
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Safety Information

Hazard Codes 
F,C
Risk Statements 
11-20/21/22-34-35-52/53
Safety Statements 
26-36/37/39-45-16-7/9-36-61
RIDADR 
UN 1277 3/PG 2
WGK Germany 
1
RTECS 
UH9100000
34
Autoignition Temperature
604 °F
TSCA 
Yes
HS Code 
2921 19 99
HazardClass 
3
PackingGroup 
II
Hazardous Substances Data
107-10-8(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 0.57 g/kg (Smyth)

MSDS

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Propylamine Usage And Synthesis

Chemical Properties

n-Propylamine is a water-white liquid with a strong irritating odor similar to that of ammonia

Chemical Properties

Propylamine is very basic, therefore it tends to readily form salts with acids. Its reactivity is similar to that described for the other short chain aliphatic amines (Astel 1961).

Uses

n-Propylamine is used as an intermediate inmany organic reactions.

Production Methods

There are several methods employed in the manufacture of propylamine. Typically, ammonia and propanol are reacted over a dehydration catalyst at high temperature and pressure. Ammonia, propanol, and hydrogen can also be reacted over a dehydrogenation catalyst such as metallic silver. Propylamine can also be synthesized from propionaldehyde and ammonia with a Raney nickel catalyst (Schweizer et al 1978).

Aroma threshold values

High strength odor; ammoniacal type; recommend smelling in a 0.10% solution or less.

General Description

A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in chemical analysis and to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Propylamine emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220].

Hazard

Highly flammable, dangerous fire risk, explosive limits in air 2–10%, use alcohol foam to extinguish. Strong irritant to skin and tissue.

Health Hazard

n-Propylamine is a strong irritant and a mod erately toxic substance. the toxic routes areinhalation, ingestion, and absorption throughthe skin. Contact of the liquid on the skincan cause burns and possibly skin sensitization. Irritation in the eyes from exposure tohigh concentrations can be severe. It is a respiratory tract irritant, similar to ethylamine.Inhalation of 2300 ppm of n-propylamine for4 hours caused labored breathing, hepatitis,and hepatocellular necrosis in rats. It is somewhat less toxic than ethylamine by oral anddermal routes.
LC50 value, inhalation (mice): 2500 mg/m3/2 hr

LD50 value, oral (rats): 570 mg/kg
LD50 value, skin (rabbits): 560 mg/kg.

Fire Hazard

Highly flammable liquid; flash point (closed cup) -37°C (-35°F); vapor density 2.0 (air = 1), vapor can travel a considerable distance to a source of ignition and flash back; autoignition temperature 318°C (604°F); fire extinguishing agent: dry chemical, CO2, or “alcohol” foam; water should be used to keep fire-exposed containers cool and to flush and dilute the spill.
n-Propylamine forms explosive mixtures in air; LEL and UEL values are 2.0% and 10.4% by volume in air, respectively. There is no report of explosion associated with this compound. It is expected to exhibit violent reactions characteristic of lower aliphatic primary amines .

Industrial uses

Propylamine is important as a chemical intermediate for rubber chemicals, dyestuffs, propyl isocyanate, textile and leather finishing resins and corrosion inhibitors. It is also used in the production of pharmaceuticals such as Prilocaine, pesticides including Profluralin and in petroleum additives. In 1976, 500 tons of propylamine were manufactured in the U.S. (HSDB 1988).

Safety Profile

Moderately toxic by inhalation, ingestion, and skin contact routes. A skin and severe eye irritant. Possibly a skin sensitizer. Very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx. Incompatible with triethynyl aluminum. See also AMINES.

Potential Exposure

Propylamine is used to make textile resins, drugs, pesticides, and other chemicals.

Metabolism

To date, there are several studies which indicate that propylamine may be metabolized in many animal species, including man. When propylamine hydrochloride was administered to humans orally, little of the parent compound was recovered in the urine (Rechenberger 1940). It has also been reported that dogs are capable of metabolizing propylamine (Bernhard 1938). McEwen et al (1966) demonstrated that monoamine oxidase, purified from rabbit serum, was capable of oxidizing propylamine, although less actively than substituted phenylethylamines such as dopamine. Further characterization revealed that the protonated amine is bound by an unprotonated enzyme group, that the enzyme active site is composed of hydrophobic residues, and that interaction of the amine residues determines maximal velocity and affinity constant (McEwen and Sober 1967). Oxidation of the amine could be stimulated by the presence of aliphatic alcohols which apparently bond in a tertiary complex with the enzyme and substrate, thereby increasing the effectiveness of substrate binding.
Other investigators have provided evidence that propylamine may not be a substrate for tissue monoamine oxidase. When given intraperitoneally to rats it had no effect on the liver enzyme and little effect on activity in the brain (Valiev 1974). Early work by Pugh and Quastel (1937) indicated that slices of rat brain did not metabolize propylamine.

Shipping

UN1277 Propylamine, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.

Purification Methods

Distil the amine from zinc dust, under reduced pressure, in an atmosphere of nitrogen. [Beilstein 4 IV 464.]

Incompatibilities

Vapors may form explosive mixture with air. Violent reaction on contact with oxidizers and mercury, strong acids; organic anhydrides; isocyanates, aldehydes, nitroparrafins, halogenated hydrocarbons; alcohols and many other compounds. Attacks many metals and alloys, especially those of copper. Aqueous solution is acidic and may attack glass.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

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J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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Alfa Aesar
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400-610-6006; 021-67582000
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TCI (Shanghai) Development Co., Ltd.
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021-67121386 / 800-988-0390
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Sales-CN@TCIchemicals.com
Beijing dtftchem Technology Co., Ltd.
Tel:
010-60275820-
Email:
dtftchem@sina.com;
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