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Isoflurane

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Isoflurane Basic information

Product Name:
Isoflurane
CAS:
26675-46-7
MF:
C3H2ClF5O
MW:
184.49
EINECS:
247-897-7
Mol File:
26675-46-7.mol
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Isoflurane Chemical Properties

Melting point:
48.5°C
Boiling point:
49 °C
Density 
1.45
vapor pressure 
238 mmHg ( 20 °C)
refractive index 
1.3002
Flash point:
48-49°C
solubility 
Practically insoluble in water, miscible with ethanol and trichloroethylene.
form 
neat
Specific Gravity
approximate 1.50
Water Solubility 
Soluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.
Merck 
14,5175
BRN 
1852087
Stability:
Stable.
InChIKey
PIWKPBJCKXDKJR-UHFFFAOYSA-N
CAS DataBase Reference
26675-46-7(CAS DataBase Reference)
NIST Chemistry Reference
1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether(26675-46-7)
EPA Substance Registry System
Isoflurane (26675-46-7)
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Safety Information

Hazard Codes 
F,T,Xn
Risk Statements 
36/37/38-67-48/20
Safety Statements 
26-36/37/39-24/25
RIDADR 
UN 3334
WGK Germany 
3
RTECS 
KN6799000
Hazard Note 
Flammable/Toxic
HS Code 
2909191800

MSDS

  • Language:EnglishProvider:ALFA
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Isoflurane Usage And Synthesis

Chemical Properties

colourless liquid

Uses

Isoflurane is a halogenated ether used for inhalational anesthesia. Recent studies suggest that there might be a relationship between administration of isoflurane and postoperative cognitive dysfunct ion (POCD).

Uses

Solvent and dispersant for fluorinated materials.

brand name

Forane (Baxter Healthcare).

Biological Functions

Isoflurane (Forane) is a structural isomer of enflurane and produces similar pharmacological properties: some analgesia, some neuromuscular blockade, and depressed respiration. In contrast, however, isoflurane is considered a particularly safe anesthetic in patients with ischemic heart disease, since cardiac output is maintained, the coronary arteries are dilated, and the myocardium does not appear to be sensitized to the effects of catecholamines. Also, blood pressure falls as a result of vasodilation, which preserves tissue blood flow. Isoflurane causes transient and mild tachycardia by direct sympathetic stimulation; this is particularly important in the management of patients with myocardial ischemia.
Unlike enflurane, isoflurane does not produce a seizurelike EEG pattern. Furthermore, the metabolic transformation of isoflurane is only one-tenth that of enflurane, so fluoride production is quite low. Among the halogenated hydrocarbons, isoflurane is one of the most popular, since it preserves cardiovascular stability and causes a low incidence of untoward effects.

General Description

Isoflurane is a volatile liquid (bp=48.5°C) with an MAC of1.15, a blood:gas partition coefficient of 1.43 and high solubilityin fat. Isoflurane is a structural isomer of enflurane. Itis a known respiratory irritant, but less so than desflurane.Approximately 0.2% of the administered drug undergoesmetabolism, the rest is exhaled unchanged. The metabolismof isoflurane yields low levels of the nephrotoxic fluoride ionas well as a potentially hepatotoxic trifluoroacetylating compound). The relatively low concentrations ofthese compounds have resulted in very low risks of hepatotoxicityand nephrotoxicity. There have been no reports ofseizures caused by isoflurane and only transient increases inheart rate have been reported.

Veterinary Drugs and Treatments

Isoflurane is an inhalant anesthetic that has some distinct advantages over either halothane or methoxyflurane due to its lessened myocardial depressant and catecholamine sensitizing effects, and the ability to use it safely in patients with either hepatic or renal disease. Isoflurane’s higher cost than either methoxyflurane or halothane is a disadvantage.
Horses may recover more rapidly than with halothane, but be more susceptible to anesthetic associated- myopathy.

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IsofluraneSupplierMore

Lianyungang Xuanyuan Chemical Co., Ltd Gold
Tel:
+86-0518-85415818 18000194506
Email:
18000194506@qq.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
PharmaBlock Sciences (Nanjing),Inc.
Tel:
Email:
sales@pharmablock.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
Alfa Aesar
Tel:
400-610-6006; 021-67582000
Email:
saleschina@alfa-asia.com
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