Isoflurane Chemical Properties
- Melting point:
- Boiling point:
- 49 °C
- vapor pressure
- 238 mmHg ( 20 °C)
- refractive index
- Flash point:
- Practically insoluble in water, miscible with ethanol and trichloroethylene.
- Specific Gravity
- approximate 1.50
- Water Solubility
- Soluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.
- CAS DataBase Reference
- 26675-46-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether(26675-46-7)
- EPA Substance Registry System
- Isoflurane (26675-46-7)
Isoflurane Usage And Synthesis
Isoflurane is a halogenated ether used for inhalational anesthesia. Recent studies suggest that there might be a relationship between administration of isoflurane and postoperative cognitive dysfunct ion (POCD).
Solvent and dispersant for fluorinated materials.
Forane (Baxter Healthcare).
Isoflurane (Forane) is a structural isomer of enflurane
and produces similar pharmacological properties: some
analgesia, some neuromuscular blockade, and depressed
respiration. In contrast, however, isoflurane is considered
a particularly safe anesthetic in patients with ischemic
heart disease, since cardiac output is maintained,
the coronary arteries are dilated, and the myocardium
does not appear to be sensitized to the effects of catecholamines.
Also, blood pressure falls as a result of vasodilation,
which preserves tissue blood flow. Isoflurane
causes transient and mild tachycardia by direct sympathetic
stimulation; this is particularly important in the
management of patients with myocardial ischemia.
Unlike enflurane, isoflurane does not produce a seizurelike EEG pattern. Furthermore, the metabolic transformation of isoflurane is only one-tenth that of enflurane, so fluoride production is quite low. Among the halogenated hydrocarbons, isoflurane is one of the most popular, since it preserves cardiovascular stability and causes a low incidence of untoward effects.
Isoflurane is a volatile liquid (bp＝48.5°C) with an MAC of1.15, a blood:gas partition coefficient of 1.43 and high solubilityin fat. Isoflurane is a structural isomer of enflurane. Itis a known respiratory irritant, but less so than desflurane.Approximately 0.2% of the administered drug undergoesmetabolism, the rest is exhaled unchanged. The metabolismof isoflurane yields low levels of the nephrotoxic fluoride ionas well as a potentially hepatotoxic trifluoroacetylating compound). The relatively low concentrations ofthese compounds have resulted in very low risks of hepatotoxicityand nephrotoxicity. There have been no reports ofseizures caused by isoflurane and only transient increases inheart rate have been reported.
Veterinary Drugs and Treatments
Isoflurane is an inhalant anesthetic that has some distinct advantages
over either halothane or methoxyflurane due to its lessened
myocardial depressant and catecholamine sensitizing effects, and
the ability to use it safely in patients with either hepatic or renal
disease. Isoflurane’s higher cost than either methoxyflurane or halothane
is a disadvantage.
Horses may recover more rapidly than with halothane, but be more susceptible to anesthetic associated- myopathy.
- ISOFLURANE RELATED COMPOUND A (0.1 ML) (1-CHLORO-2,2,2-TRIFLUOROETHYL CHLORODIFLUOROMETHYL ETHER)
- Diethyl ether
- 1,1-DICHLORO-2,2,2-TRIFLUOROETHYL CHLORODIFLUOROMETHYL ETHER
- DIFLUOROMETHYL 2,2,2-TRIFLUOROETHYL ETHER
- 1,1-DICHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER
- Chloroacetic acid
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