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Pyrimethamine Structure

Pyrimethamine

Chemical Properties

Melting point 233-234°C
Boiling point 393.35°C (rough estimate)
Density  1.2171 (rough estimate)
refractive index  1.6110 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
pka pKa 7(t=20.0) (Uncertain)
color  White to Off-White
Water Solubility  <0.01 g/100 mL at 21 ºC
λmax 276nm(lit.)
Merck  14,7985
BRN  219864
BCS Class 2 (CLogP), 4 (LogP),3
Stability Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference 58-14-0(CAS DataBase Reference)
IARC 3 (Vol. 13, Sup 7) 1987
NIST Chemistry Reference Pyrimethamine(58-14-0)
EPA Substance Registry System Pyrimethamine (58-14-0)

Safety Information

Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
RIDADR  3249
WGK Germany  3
RTECS  UV8140000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29335990
Hazardous Substances Data 58-14-0(Hazardous Substances Data)
Toxicity LD50 oral in rat: 440mg/kg

MSDS

Usage And Synthesis

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