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Propiophenone

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Propiophenone Basic information

Product Name:
Propiophenone
CAS:
93-55-0
MF:
C9H10O
MW:
134.18
EINECS:
202-257-6
Mol File:
93-55-0.mol
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Propiophenone Chemical Properties

Melting point:
17-19 °C(lit.)
Boiling point:
218 °C(lit.)
Density 
1.009 g/mL at 25 °C(lit.)
vapor pressure 
1 mm Hg ( 50 °C)
refractive index 
n20/D 1.526(lit.)
FEMA 
3469 | PROPIOPHENONE
Flash point:
190 °F
storage temp. 
Store below +30°C.
solubility 
Difficult to mix.
form 
Liquid
color 
Clear colorless to light yellow
Water Solubility 
INSOLUBLE
JECFA Number
824
Merck 
14,7830
BRN 
606215
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
KRIOVPPHQSLHCZ-UHFFFAOYSA-N
CAS DataBase Reference
93-55-0(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanone, 1-phenyl-(93-55-0)
EPA Substance Registry System
Propiophenone (93-55-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
UG7175000
TSCA 
Yes
HS Code 
2914 39 00
Hazardous Substances Data
93-55-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 4490 mg/kg LD50 dermal Rabbit 4490 mg/kg

MSDS

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Propiophenone Usage And Synthesis

Description

Propiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.

References

https://en.wikipedia.org/wiki/Propiophenone
https://pubchem.ncbi.nlm.nih.gov/compound/7148#section=Top
http://www.chemicalland21.com/industrialchem/organic/PROPIOPHENONE.htm
https://www.alfa.com/en/catalog/A15140/

Chemical Properties

Propiophenone has a strong, flowery odor.

Chemical Properties

colourless to light yellow liquid

Occurrence

Reported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.

Uses

Propiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.

Uses

In perfumery; in the synthesis of ephedrine and related Compounds.

Uses

Intermediates of Liquid Crystals

Definition

ChEBI: An aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl.

Production Methods

Propiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

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Basic information Description References Safety Related Supplier