FATTY ALCOHOL POLYGLYCOL ETHER

Nonionic surfactants, which are favored in topical formulations because they have less potential for skin irritancy compared with ionic surfactants, and certain solvents alter the emulsions coating hair/wool, thereby allowing more drug to reach the skin surface. It is postulated that the mechanism by which skin penetration enhancers increase drug transport across the skin involves increasing the fluidity and/or the hydration of the polar head groups of the lipid bilayers (29).