Tocoretinate

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Tocoretinate Basic information

Product Name:
Tocoretinate
CAS:
40516-48-1
MF:
C49H76O3
MW:
713.13
Mol File:
40516-48-1.mol
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Tocoretinate Chemical Properties

CAS DataBase Reference
40516-48-1(CAS DataBase Reference)
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Safety Information

Toxicity
LD50 in mice (mg/kg): >1000 i.v.; >2000 orally (Fukawa, 1975)
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Tocoretinate Usage And Synthesis

Description

Tretinoin tocoferil, the a-tocopherol ester of all-trans-retinoic acid, was launched for the treatment of bedsores and skin ulcers such as burn, leg, and diabetic ulcers. It is also an orally active agent for gastric ulcer treatment. Tretinoin tocoferil represents a new class of antiulcer drugs which act by directly promoting tissue repair, distinguished from common drugs that exert an indirect function by suppression of acid-secretion and mucosa protection. The mode of its action has been proposed to relate to its ability to stimulate DNA synthesis of growth-arrested human skin fibroblasts by promoting expression of the epidermal growth factor receptor.

Originator

Nisshin Flour Milling (Japan)

brand name

Olcenon

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TocoretinateSupplierMore

Wuhan Wei Shunda Technology Development Co., Ltd.
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LGM Pharma
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Chengdu XiYa Chemical Technology Co., Ltd.
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Hangzhou Yuhao Chemical Technology Co., Ltd
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Chengdu HuaXia Chemical Reagent Co. Ltd
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400-1166-196;028-84555506- ;028-84555506-
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cdhxsj@163.com;cdhxsj@163.com;cdhxsj@163.com
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