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Octyl gallate

Basic information Description References Safety Related Supplier

Octyl gallate Basic information

Product Name:
Octyl gallate
CAS:
1034-01-1
MF:
C15H22O5
MW:
282.33
EINECS:
213-853-0
Mol File:
1034-01-1.mol
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Octyl gallate Chemical Properties

Melting point:
101-104 °C(lit.)
Boiling point:
262.5°C (estimate)
Density 
1.0984 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
0-6°C
solubility 
soluble2.5%, clear, colorless (AcOH (MEOH))
pka
7.94±0.25(Predicted)
form 
neat
Water Solubility 
20mg/L(29.99 ºC)
BRN 
2132305
CAS DataBase Reference
1034-01-1(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 3,4,5-trihydroxy-, octyl ester (1034-01-1)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-43
Safety Statements 
24-37
WGK Germany 
1
RTECS 
LW8225000
TSCA 
Yes
HS Code 
2918 29 00
Toxicity
LD50 orally in Rabbit: 1960 mg/kg

MSDS

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Octyl gallate Usage And Synthesis

Description

Octyl gallate is the ester formed by 1-octanol and gallic acid. It can be used as an antioxidant and preservative to be supplemented to the food. It has been demonstrated to be an effective fungicide being capable of inhibiting the growth of S. cerevisiae and Z. bailii as it can inhibit the fluidity of the cell membrane through acting as a nonionic surface-active agent. It is also capable of killing both DNA and RNA viruses with a relatively moderate cytotoxicity. For example, it has the potential to treat influenza. Octyl gallate also has certain bactericidal activity, being capable of treating the infections associated with enterococci.

References

[1]Ken-Ichi, Fujita, and K. Isao. "Antifungal activity of octyl gallate. " International Journal of Food Microbiology 79.3(2002):1
[2]Gutiérrez-Fernández, J, et al. "Antimicrobial activity of binary combinations of natural and synthetic phenolic antioxidants against Enterococcus faecalis. " Journal of Dairy Science 96.8(2013):4912-20.93.
[3] Yamasaki, H, et al. "Antiviral effect of octyl gallate against influenza and other RNA viruses. " International Journal of Molecular Medicine 19.4(2007): 685-688.

Description

During the 1940s, propyl gallate and several other alkyl gallates were allowed for use in foods in a number of countries. Since gallic acid contains three phenolic hydroxyl groups, it is a rather potent antioxidant; however, the propyl ester has a significant degree of water solubility. As a consequence, propyl gallate tends to partition into any water phase which may be present and to complex with iron salts to give bluish black colors. Also, its relatively poor resistance to heat degradation makes it ineffective for baking and frying applications. The higher alkyl gallates (butyl and octyl) are more fat soluble.

Chemical Properties

White powder

Uses

Used in treatment of alcohol dependence.

Uses

Octyl gallate is an antioxidant that is used as a preservation agent in a wide variety of foods, oils, and cosmetics.

Definition

ChEBI: A gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.

Contact allergens

Octyl gallate, a gallate ester (E 311), is an antioxidant added to food and cosmetics to prevent oxidation of unsaturated fatty acids. Cases were sparsely reported in food industry or from lipsticks. Patch tests are frequently irritant.

Safety Profile

A poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.

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Octyl gallateSupplierMore

JIURUI BIOLOGY & CHEMISTRY CO.,LTD. Gold
Tel:
86-744-8561910/18507445225
Email:
info@jiuruibiochem.com/sales@jiuruibiochem.com/sales13@jiuruibiochem.com
Shanghai RC Chemicals Co., Ltd. Gold
Tel:
21-58661250-
Email:
3059772675@qq.com;
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Alfa Aesar
Tel:
400-610-6006; 021-67582000
Email:
saleschina@alfa-asia.com
TAIYUAN RHF CO.,LTD.
Tel:
+86 351 7031519
Email:
sales@RHFChem.com
Basic information Description References Safety Related Supplier