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4-Hydroxy-3-methoxybenzyl alcohol

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4-Hydroxy-3-methoxybenzyl alcohol Basic information

Product Name:
4-Hydroxy-3-methoxybenzyl alcohol
CAS:
498-00-0
MF:
C8H10O3
MW:
154.16
EINECS:
207-852-4
Mol File:
498-00-0.mol
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4-Hydroxy-3-methoxybenzyl alcohol Chemical Properties

Melting point:
110-117 °C(lit.)
Boiling point:
237.52°C (rough estimate)
Density 
1.1690 (rough estimate)
FEMA 
3737 | VANILLYL ALCOHOL
refractive index 
1.4620 (estimate)
storage temp. 
Store below +30°C.
pka
9.75±0.18(Predicted)
form 
Fine Crystalline Powder
color 
Off-white to beige
Water Solubility 
Soluble in 95% ethanol (5 %), water, and oils.
JECFA Number
886
BRN 
1910044
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference
498-00-0(CAS DataBase Reference)
NIST Chemistry Reference
4-Hydroxy-3-methoxybenzyl alcohol(498-00-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29095090

MSDS

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4-Hydroxy-3-methoxybenzyl alcohol Usage And Synthesis

Description

4-hydroxy-3-methoxybenzyl alcohol (also known as vanillyl alcohol) is often used as a deodorant component that is active in preventing the formation of body odor. It can also be used as a flavoring agent. Recent studies have also demonstrated that it has certain pharmacological effects. For example, it has been confirmed that it has certain neuro-protective effects through suppressing the oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells, making it a potential candidate for the treatment of neurodegenerative diseases such as Parkinson’s disease.

Chemical Properties

Vanillyl alcohol has a mild, sweet, balsamic, vanilla-like odor.

Chemical Properties

crystalline white to off-white powder

Taste threshold values

Sweet, creamy and milky with a slightly powdery mouthfeel.

References

Brune, I, et al. "Under the influence of the active deodorant ingredient 4-hydroxy-3-methoxybenzyl alcohol, the skin bacterium Corynebacterium jeikeium moderately responds with differential gene expression." Journal of Biotechnology 127.1(2006):21-33.
Hsu, Lun Chung, Z. H. Wen, and K. Y. Lee. "Use of vanillyl alcohol for the treatment of Parkinson's disease." (2009).
Kim, I. S., D. K. Choi, and H. J. Jung. "Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells." Molecules 16.7(2011):5349.

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