N-乙酰-L-胱氨酸
N-乙酰-L-胱氨酸 性质
| 熔点 | 147-149 °C(Solv: ethanol (64-17-5)) |
|---|---|
| 沸点 | 441.0±40.0 °C(Predicted) |
| 密度 | 1.226±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | H2O：≥20mg/mL |
| 酸度系数(pKa) | 9.21±0.10(Predicted) |
| 形态 | 冻干粉 |
| 颜色 | 白色至类白色 |
| InChI | InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1 |
| InChIKey | ZLCOWUKVVFVVKA-GDVGLLTNSA-N |
| SMILES | C(N)(=O)[C@@H](NC(C)=O)CS |
N-乙酰-L-胱氨酸 用途与合成方法
| Target | Value |
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NF-κB
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HIF-1α
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ROS
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N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR). N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death.
N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, i.p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats.
N-乙酰-L-胱氨酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-110256 | N-乙酰-L-胱氨酸 | 38520-57-9 | 1mg | 363 |
| 2024-01-25 | HY-110256 | N-乙酰-L-胱氨酸 | 38520-57-9 | 5mg | 800 |
