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Nitrilotriacetic acid

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Nitrilotriacetic acid Basic information

Product Name:
Nitrilotriacetic acid
CAS:
139-13-9
MF:
C6H9NO6
MW:
191.14
EINECS:
205-355-7
Mol File:
139-13-9.mol
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Nitrilotriacetic acid Chemical Properties

Melting point:
245 °C (dec.)(lit.)
Boiling point:
326.86°C (rough estimate)
Density 
1.5784 (rough estimate)
refractive index 
1.4860 (estimate)
Flash point:
100 °C
storage temp. 
Store at RT.
solubility 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka
3.03, 3.07, 10.70(at 20℃)
form 
Powder
color 
White
Water Solubility 
Insoluble. <0.01 g/100 mL at 23 ºC
λmax
λ: 260 nm Amax: 1.5
λ: 280 nm Amax: 0.05
Merck 
14,6579
BRN 
1710776
CAS DataBase Reference
139-13-9(CAS DataBase Reference)
NIST Chemistry Reference
Nitrilotriacetic acid(139-13-9)
EPA Substance Registry System
Nitrilotriacetic acid (139-13-9)
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Safety Information

Hazard Codes 
Xn,T
Risk Statements 
22-36-40-36/37/38-45-20/21/22
Safety Statements 
26-36/37-45-36/37/39-53
RIDADR 
2811
WGK Germany 
2
RTECS 
AJ0175000
21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29224995
Hazardous Substances Data
139-13-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1100 mg/kg

MSDS

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Nitrilotriacetic acid Usage And Synthesis

Chemical Properties

White, crystalline powder.Insoluble in water and most organic solvents; forms mono-, di-, and tribasic salts that are water soluble. Combustible. 70% biodegradable.

Chemical Properties

Nitrilotriacetic acid is a crystalline compound.

Uses

Nitrilotriacetic acid is a chelating agent which forms coordination compounds with metal ions. Nitrilotriacetic acid is used in complexometric titrations and as well as for protein isolation and purif ication in the His-tag method.

Uses

Used in sequestration of metals; chelometric analysis.

General Description

Odorless white solid. Sinks in and mixes with water.

Air & Water Reactions

Water Insoluble.

Reactivity Profile

Nitrilotriacetic acid is incompatible with strong oxidizers, aluminum, copper, copper alloy and nickel. Nitrilotriacetic acid is also incompatible with strong bases.

Hazard

Possible carcinogen.

Health Hazard

Toxicity and health hazard of these compounds are low. Contact with eyes causes irritation.

Fire Hazard

Flash point data for Nitrilotriacetic acid are not available; however, Nitrilotriacetic acid is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Nitrilotriacetic acid (NTA) was used as a phosphate replacement in laundry detergents in the late 1960s. In 1971, the use of NTA was discontinued. The possibility of resumed use arose in 1980. NTA is now used in laundry detergents in states where phosphates are banned. NTA is also used as a boiler feed-water additive at a maximum use level of 5 ppm of trisodium salt. Currently, the remaining nondetergent uses of NTA are for water treatment, textile treatment; metal plating and cleaning; and pulp and paper processing.

Carcinogenicity

Nitrilotriacetic acid is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise it from water and dry it at 110o. [Beilstein 4 IV 2441.]

Incompatibilities

Dust may form explosive mixture with air. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Attacks aluminum, copper, copper alloy and nickel.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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Nitrilotriacetic acidSupplierMore

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
Email:
sh@meryer.com
Alfa Aesar
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400-610-6006; 021-67582000
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saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
Energy Chemical
Tel:
021-58432009
Email:
sales8178@energy-chemical.com
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